Microbiology: A Systems Approach
Microbiology: A Systems Approach
5th Edition
ISBN: 9781259706615
Author: Marjorie Kelly Cowan Professor
Publisher: McGraw-Hill Education
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Chapter 16, Problem 3CTQ

a.

Summary Introduction

To determine:

Whether each of the following transfusions would be immunologically compatible.

Type A donor into a type B recipient.

Type B donor into a type AB recipient.

Type O donor into a type O+ recipient.

Introduction:

ABO blood group system is the classification of human blood based on the presence or absence of inherited antigens A and B on the surface of the red blood cells (erythrocytes). Persons may four type of blood group type A, type B, type O, or type AB blood. A blood group is further classified in the basis of presence or absence of RH antigen factor on the surface of erythrocytes.

b.

Summary Introduction

To explain:

How xenotransplantation might be successful in light of the immune system’s robust ability to recognize the foreign antigen.

Introduction:

Transplantation is the surgical procedure for removing tissue from one site and transferring them to another on the same body, or from another person, without bringing the blood supply of the donor with it. Instead, a new blood supply grows develops after it is placed.

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a. Define epitope; compare polyclonal antibodies to monoclonal antibodies. b. Describe an immunoassay (and the steps involved) in which you could detect the presence of a particular antigen. c. Describe an immunoassay (and the steps involved) in which you could detect the presence of a particular antibody.
i. Draw a schematic diagram of a typical IgG molecule and label each of the following parts: H chains, L chains, intrachain disulfide bonds, hinge, Fab, Fc, and all the domains. Indicate which domains are involved in antigen binding.
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Immune System Diseases and Disorders; Author: Heather Davis;https://www.youtube.com/watch?v=3lIkxNv7MVI;License: Standard youtube license