Biology (MindTap Course List)
11th Edition
ISBN: 9781337392938
Author: Eldra Solomon, Charles Martin, Diana W. Martin, Linda R. Berg
Publisher: Cengage Learning
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Chapter 15.4, Problem 1C
Summary Introduction
To predict: The function of the gene in C. elegans that resulted in the inability of worm to touch when it is exposed to an RNAi molecule homologous to a non-protein-coding RNA gene.
Concept introduction: MicroRNAs (miRNAs) and small interfering RNAs (siRNAs) are non-coding RNA sequences that regulate the gene function and expression. They are approximately 20-30
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Chapter 15 Solutions
Biology (MindTap Course List)
Ch. 15.1 - Prob. 1LOCh. 15.1 - Explain how gel electrophoresis is used to...Ch. 15.1 - Describe how PCR is used to amplify a specific...Ch. 15.1 - Compare the possible differences between a...Ch. 15.1 - Prob. 1CCh. 15.1 - Different forms of a protein are produced in the...Ch. 15.1 - What advantages does the PCR method have over gene...Ch. 15.2 - Describe the features of a typical CRISPR locus in...Ch. 15.2 - Explain the function of CRISPR in bacterial cells.Ch. 15.2 - Compare CRISPR-based endonucleases with...
Ch. 15.2 - Prob. 8LOCh. 15.2 - Prob. 1CCh. 15.2 - Prob. 2CCh. 15.2 - Prob. 3CCh. 15.3 - Prob. 9LOCh. 15.3 - Prob. 10LOCh. 15.3 - Discuss how qPCR, DNA microarrays (DNA chips), and...Ch. 15.3 - Explain how you would compare the expression of a...Ch. 15.3 - Prob. 2CCh. 15.4 - Describe how genome-wide association studies have...Ch. 15.4 - Explain how targeted gene silencing and knockout...Ch. 15.4 - Prob. 1CCh. 15.5 - Describe at least one important application of DNA...Ch. 15.5 - Prob. 1CCh. 15.5 - What are short tandem repeats (STRs), and why are...Ch. 15.5 - Why do gene targeting and mutagenesis screening in...Ch. 15.6 - Prob. 15LOCh. 15.6 - Prob. 16LOCh. 15.6 - Prob. 1CCh. 15.6 - Prob. 2CCh. 15.7 - Describe at least two safety issue associated with...Ch. 15.7 - What are some of the environment concerns...Ch. 15 - A plasmid (a) can be used as a DNA vector (b) is a...Ch. 15 - DNA molecules with complementary sticky ends...Ch. 15 - Prob. 3TYUCh. 15 - Which technique rapidly replicated specific DNA...Ch. 15 - Prob. 5TYUCh. 15 - A cDNA clone contains (a) introns (b) exons (c)...Ch. 15 - Prob. 7TYUCh. 15 - Gel electrophoresis separates nucleic acids on the...Ch. 15 - A CRISPR locus in a bacterium contains (a) short...Ch. 15 - DNA molecular with complementary sticky ends...Ch. 15 - These highly polymorphic molecular markers are...Ch. 15 - Prob. 12TYUCh. 15 - Prob. 13TYUCh. 15 - Prob. 14TYUCh. 15 - EVOLUTION LINK DNA technology, such as the...Ch. 15 - SCIENCE, TECHNOLOGY, AND SOCIETY What are some...
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- Signal transduction pathways are important mechanisms for cell-to-cell communication in multicellular organisms. How do the target cells typically respond when they receive signals from neighboring cells during very early stages of embryo development? A. The target cells move to one of the poles to establish the anterior-posterior body axis. B. The target cells undergo changes in gene expression, sending them down a specific developmental path. C. The target cells stop dividing so the neighboring cells have time to get to the same stage of development. D. The target cells activate a collection of miRNAs to accelerate transcription and cell division.arrow_forwardAnother way to study the role of proteins (e.g., transcription factors) that function in development is to microinject the mRNA that encodes a protein, or the purified protein itself, into an oocyte or embryo, and then determine how this affects the subsequent development of the embryo, larva, and adult. For example, if Bicoid protein is injected into the posterior region of an oocyte, the resulting embryo will develop into a larva that has anterior structures at both ends. Based on your understanding of the function of each developmental gene, what would be the predicted phenotype if the following proteins or mRNAs were injected into normal oocytes? A. Nanos mRNA injected into the anterior end of an oocyte B. Antp protein injected into the posterior end of an embryo C. Toll mRNA injected into the dorsal side of an early embryoarrow_forwardExpression of a homeotic gene in the wrong tissue in Drosophila results in the development of an inappropriate body part from that tissue. Explain why this happens and how it shows that homeotic genes are positive regulators of developmental pathways.arrow_forward
- Discuss the role of homeotic genes in development. Explain what happens to the phenotype of a fruit fly when a gain-of-function mutation in a homeotic gene causes the protein to be expressed in an abnormal region of the embryo. What are the consequences of a loss-of-function mutation in such a gene?arrow_forwardPropose one or more explanations for why Hox genes exhibit a relation between their order on the chromosome and the timing of their expression, with Hox genes at one end of the complex expressed early and those at the other end expressed later.arrow_forwardSuppose you want to determine whether a particulargene X is important for specification of the pharynx,but mutations in this same gene disrupt embryonicdevelopment well before pharyngeal structures appear.How could you use myo-2::GFP, the myo-2 promoter,the DNA sequence of gene X, and your knowledge ofRNA interference (RNAi) to generate worms that lackgene X expression in the pharynx but express gene Xin all other tissues in which it is expressed in wildtype C. elegans?arrow_forward
- A C. elegans (nematode) gene called par-1 helps todetermine the AP axis of the animal early in development. Scientists determined that par-1 is pleiotropic—it also has a later function in forming the vulva of theadult animal. How could researchers circumvent thelethality of par-1− mutants to observe the later function of the par-1 gene? (Hint: C. elegans larvae caneat bacteria expressing RNAi for any gene.)arrow_forwardWhat is the function of the Pax 6 gene in the mouse eye reference to HOX gene?arrow_forward) Explain how and why dorsal/ventral polarity will be affected in fly Question 3 (1. embryos carrying the following mutations; also in each case darken in the area of the cells in the cross-sectional view of the fly embryo which are expected to express the paulie gene. D = dorsal; V = ventral. a) a mutation which results in the deletion of the cytoplasmic domain of the Cookie protein. b) A mutation which results in a constitutively active Bombe protein, i.e. the Bombe protein is always in an activated state. c) A mutation which causes the Pickle protein to be retained in the cytoplasm of the embryo.arrow_forward
- You inject bicoid MRNA into the posterior end of a fertilized fruit fly egg just prior to the first cleavage. How will the experiment affect Hox gene expression in this fly? How will it affect the fly embryo's anatomy? Explain your answer, demonstrating your understanding of the role bicoid and Hox genes play in development.arrow_forwardYou isolate a glp-1 mutation of C. elegans and discoverthat the DNA region encoding the spatial control region(SCR) has been deleted. What will the GLP-1 protein expression pattern be in a four-cell embryo in mutant heterozygotes? In mutant homozygotes?arrow_forwarda. Explain how you could use worms transformedwith myo-2::GFP to find mutations that disrupt thestructure of the pharynx. How would the presenceof the transgene facilitate the mutant screen?b. Nematodes homozygous for loss-of-function mutations in a gene called pha-4 have no detectablepharyngeal structures. How could you use myo2::GFP to determine if pha-4 is a master regulatory gene that directs development of the pharynxin a manner similar to the way Pax-6/eyeless controls eye development?arrow_forward
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