Levels of protein structure (a) Primary structure Amino end H H R. H R4 H Re Carboxyl end H|| C C N. IH | H -- R, H R5 (b) Secondary structure R H H- R. H.... 0=C N-H. N-H.. ... H .• OC H N-H. R H C-R N-H -H H R Hydrogen bonds between amino acids at different locations in polypeptide chain H R HR a helix Pleated sheet (c) Tertiary structure (d) Quaternary structure Heme. Heme group B polypeptide FIGURE 9-3 A protein can have four levels of structure. (a) Primary structure. The sequence of amino acids defined by their R groups. (b) Secondary structure. The polypeptide can form a helical structure (an az helix) or a zigzag structure (a B-pleated sheet). The B-pleated sheet has two polypeptide segments arranged in opposite polarity, as indicated by the arrows. (c) Tertiary structure. The heme group is a nonprotein ring structure with an iron atom at its center. (d) Quatemary structure illustrated by hemoglobin, which is composed of four polypeptide subunits: two a subunits and two B subunits.
Levels of protein structure (a) Primary structure Amino end H H R. H R4 H Re Carboxyl end H|| C C N. IH | H -- R, H R5 (b) Secondary structure R H H- R. H.... 0=C N-H. N-H.. ... H .• OC H N-H. R H C-R N-H -H H R Hydrogen bonds between amino acids at different locations in polypeptide chain H R HR a helix Pleated sheet (c) Tertiary structure (d) Quaternary structure Heme. Heme group B polypeptide FIGURE 9-3 A protein can have four levels of structure. (a) Primary structure. The sequence of amino acids defined by their R groups. (b) Secondary structure. The polypeptide can form a helical structure (an az helix) or a zigzag structure (a B-pleated sheet). The B-pleated sheet has two polypeptide segments arranged in opposite polarity, as indicated by the arrows. (c) Tertiary structure. The heme group is a nonprotein ring structure with an iron atom at its center. (d) Quatemary structure illustrated by hemoglobin, which is composed of four polypeptide subunits: two a subunits and two B subunits.
Biochemistry
9th Edition
ISBN:9781319114671
Author:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher:Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Chapter1: Biochemistry: An Evolving Science
Section: Chapter Questions
Problem 1P
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Question
Using the quarternary structure of hemoglobin shown in
Figure 9-3(d), explain in structural terms how a mutation in the β subunit protein could be suppressed by a
mutation in the a subunit gene.
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