Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 14, Problem 1PDQ
HOW DO WE KNOW?
In this chapter, we focused on how gene mutations arise and how cells repair DNA damage. In particular, we discussed spontaneous and induced mutations, DNA repair methods, and transposable elements. Based on your knowledge of these topics, answer several fundamental questions:
(a) How do we know that mutations occur spontaneously?
(b) How do we know that certain chemicals and wavelengths of radiation induce mutations in DNA?
(c) How do we know that DNA repair mechanisms detect and correct the majority of spontaneous and induced mutations?
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Students have asked these similar questions
Which of the followings statements are true about DNA polymerase?
1.) It can only go in one direction, meaning the lagging strand can't be synthesized continuously.
2.) It cannot start a DNA strand from scratch, so another enzyme is needed to create "primers" as a starting point.
3.) It cannot copy epigenetic marks (such as methyl groups) on its own; these must be "copied" onto the daughter DNA strand by other enzymes after DNA replication.
4.) All of the above
Discuss the following statement: “the DNA repair enzymes that fix deamination and depurination damage must preferentially recognize such damage on newly synthesized DNA strands.”
a. Propose three different mutations to prevent initiation, elongation, and termination of bacterial
DNA replication, respectively. Explain how/why each mutation would prevent its respective step.
(Hint: mutations can be in genes that encode proteins or regulatory DNA sequences)
b. In the early 1900s, Avery, MacLeod, and McCarty performed an experiment in bacterial cells to
determine whether DNA, RNA, or protein functions as the 'transforming molecule' (i.e. the genetic
material). In your own words, how did their experiment (depicted in the figure below) help to
answer that question?
Chapter 14 Solutions
Essentials of Genetics (9th Edition) - Standalone book
Ch. 14 - CASE STUDY| Genetic dwarfism Seven months...Ch. 14 -
CASE STUDY | Genetic dwarfism
Seven months...Ch. 14 -
CASE STUDY| Genetic dwarfism
Seven months...Ch. 14 - CASE STUDY | Genetic dwarfism Seven months...Ch. 14 -
HOW DO WE KNOW?
1. In this chapter, we focused on...Ch. 14 - Review the Chapter Concepts list on page 257....Ch. 14 - What is a spontaneous mutation, and why are...Ch. 14 -
4. Why would a mutation in a somatic cell of a...Ch. 14 - Why is a random mutation more likely to be...Ch. 14 - Most mutations in a diploid organism are...
Ch. 14 - What is meant by a conditional mutation?Ch. 14 -
8. Describe a tautomeric shift and how it may...Ch. 14 - Contrast and compare the mutagenic effects of...Ch. 14 - Why are frameshift mutations likely to be more...Ch. 14 - Why are X rays more potent mutagens than UV...Ch. 14 -
12. DNA damage brought on by a variety of natural...Ch. 14 - Contrast the various types of DNA repair...Ch. 14 -
14. Mammography is an accurate screening...Ch. 14 - Describe how the Ames test screens for potential...Ch. 14 - What genetic defects result in the disorder...Ch. 14 - In a bacterial culture in which all cells are...Ch. 14 - Human equivalents of bacterial DNA mismatch repair...Ch. 14 - A number of different types of mutations in the...Ch. 14 -
20. Some mutations that lead to diseases such as...Ch. 14 - In maize, a Ds or Ac transposon can cause...Ch. 14 -
22. Presented here are hypothetical findings from...Ch. 14 -
23. Cystic fibrosis (CF) is a severe autosomal...Ch. 14 -
24. Electrophilic oxidants are known to create...Ch. 14 - Skin cancer carries a lifetime risk nearly equal...Ch. 14 -
26. The initial discovery of IS elements in...Ch. 14 -
27. It is estimated that about 0.2 percent of...Ch. 14 -
28. It has been noted that most transposons in...Ch. 14 - Two related forms of muscular dystrophy–Duchenne...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Hereditary nonpolyposis colon cancer (HNPCC) is caused by mutations in proteins from one of the DNA repair pathways. Which pathway is it and what are the protein activities occuring in the pathway?arrow_forwardDNA repair enzymes preferentially repair mis- matched bases on the newly synthesized DNA strand, using the old DNA strand as a template. If mismatches were instead repaired without regard for which strand served as template, would mismatch repair reduce repli- cation errors? Would such a mismatch repair system result in fewer mutations, more mutations, or the same number of mutations as there would have been without any repair at all? Explain your answers.arrow_forwardA DNA sequence can be represented as a string of the letters ACTG (short for adenine, cytosine, guanine, and thymine). (a) How many DNA sequences are exactly 24 letters long? (b) Given a DNA sequence of length 24, how many single letter mutations are possible? (c) Given a DNA sequence of length 24, how many double letter mutations are possible?arrow_forward
- Contrast the various types of DNA repair mechanisms known to counteract the effects of UV radiation. What is the role of visible light in repairing UV-induced mutations?arrow_forwardThere are two types of excision repair, base excision repair (BER) and nucleotide excision repair (NER). Which enzymes are used in Base excision repair in E. coli?And In nucleotide excision repair, what kind of damage is repaired by this mechanism and why are cutsmade on both sides of the damaged region of DNA?arrow_forward18) UV radiation damages DNA by causing... a) frame-shift mutations b) base substitutions c) bonds between neighboring Thymine bases - "thymine dimers" d) unzipping of the DNA molecue e) all of thesearrow_forward
- You are studying a colony of cells and determine that some of these cells have a mutated DNA polymerase I that results in loss of function of this enzyme. A) What will the effect of the mutation in DNA polymerase I be on DNA replication? In your answer make sure to describe what would be observed in the leading and lagging strand and explain your reasoning. B) Will this mutation in DNA polymerase I have an impact on another step in DNA replication? In your answer make sure to indicate whether DNA replication will be impacted or not. If it is not, explain why. If it is impacted, then describe the step that is impacted and name the molecule or enzyme involved.arrow_forwardSilent mutations that occur in DNA are quite common in living cells and usually involve no effects onphenotype. 1) Define the silent mutation in DNA?arrow_forwardDuring high stress environments, it has been found that some bacteria activate a genetic mechanism that allows them to incorporate more mutations into the DNA during replication. Would the following two enzymes be impacted by such a mechanism? In each case, provide a reason for your answer. i) DNA polymerase IIIii) Helicasearrow_forward
- The central dogma of molecular biology states simply that DNA encodes RNA, and RNA encodes protein. For each of the following processes, describe, 1) where in the cell they occur, 2) one important protein (or protein containing complex) involved 3) the result of this process. DNA replication Where?) Protein?) Result?) Transcription Where?) Protein?) Result?) Splicing Where?) Protein?) Result?) Translation Where?) Protein?) Result?)arrow_forwardDNA replication is semi-conservative, this statement means that Question 6 options: a) the new DNA molecules that are made are not identical to the original DNA molecule. b) the new DNA molecules that are made are only partially DNA since RNA primers are included. c) the new DNA molecules that are made are composed of one strand of the old DNA molecule and one strand of new DNA. d) of the two new DNA molecules made, one is entirely new DNA and one is entirely old new. e) the new DNA molecules that are made have a mixture of old and new DNA in each strand of the DNA duplex, randomly interspersed.arrow_forwardWhat is/are the attributes that make nucleotide excision repair (NER) and base excision repair (BER) similar and/or different from each other? Select the correct response: The NER pathway is the only one that can remove DNA lesions in the strand regardless of their size which is followed by attaching the correct strand, then sealed by a DNA ligase. They both use the enzyme DNA glycosylases that recognizes the damaged DNA segments and proceed with repairing the faulty base in the strand. They differ NER only repairs purine bases while BER repairs pyrimidine bases. They both remove the damaged parts of the DNA where the BER pathway corrects only the identified damaged bases which are usually non-bulky lesions. The NER pathway, on the other hand, repairs the damage by removal of bulky DNA adducts which is a short-single stranded DNA segment. They both utilize the enzyme photolyase to reverse the damages created by the faulty section of the DNA. They both remove the damaged parts of the…arrow_forward
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