Becker's World of the Cell (9th Edition)
Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 14, Problem 14.1PS

Ciliobrevins. Ciliobrevins were reported in 2012 to be specific small molecule inhibitors of the AAA+ of cytoplasmic dynein. For each of the following processes, would ciliobrevins disrupt the process or not? Explain your answers.

(a) Swimming of human sperm

(b) Contraction of smooth muscle cells

(c) Movement of materials along cilia and flagella

(d) Movement of vesicle-packaged cargo from the Golgi to the endoplasmic reticulum or cell periphery

(e) Movement of vesicles toward the minus ends of microtubules

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