Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N). Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Question

B Vitamins and Carbohydrate Metabolism (Section 7-10) 7-117 For the B vitamins below, indicate which of the follow- ing processes each vitamin is involved in as a cofactor: (1) glycolysis, (2) gluconeogenesis, (3) lactate fermenta- tion, or (4) glycogenolysis. For a given vitamin, there may be more than one correct response, or only one or none of the responses may apply. a. Thiamin c. Pantothenic acid b. Riboflavin d. Vitamin B6 CHAPTER 7 Carbohydrate Metabolism 337-f 7-118 For the B vitamins below, indicate which of the follow- ing processes each vitamin is involved in as a cofactor: (1) glycolysis, (2) gluconeogenesis, (3) lactate fermenta- tion, or (4) glycogenolysis. For a given vitamin, there may be more than one correct response, or only one or none of the responses may apply. a. Niacin b. Biotin c. Folate d. Vitamin B₁2

Answer 1

Question

Chapter 12, Problem 12.8PS

(a)

Summary Introduction

To determine: Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(b)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of degradation products in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(c)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of excessive amounts of glycogen in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(d)

Summary Introduction

To determine: Whether the given statement, “Results from an inability to regulate the synthesis of glycosaminoglycans” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(e)

Summary Introduction

To determine: Whether the given statement, “Results from an absence of functional acid hydrolases” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(f)

Summary Introduction

To determine: Whether the given statement, “Results in accumulation of lysosomes in the cell” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(g)

Summary Introduction

To determine: Whether the given statement, “Symptoms include muscle weakness and mental retardation” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(h)

Summary Introduction

To determine: Whether the given statement, “Triggers proliferation of organelles containing catalase” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

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B Vitamins and Carbohydrate Metabolism (Section 7-10) 7-117 For the B vitamins below, indicate which of the follow- ing processes each vitamin is involved in as a cofactor: (1) glycolysis, (2) gluconeogenesis, (3) lactate fermenta- tion, or (4) glycogenolysis. For a given vitamin, there may be more than one correct response, or only one or none of the responses may apply. a. Thiamin c. Pantothenic acid b. Riboflavin d. Vitamin B6 CHAPTER 7 Carbohydrate Metabolism 337-f 7-118 For the B vitamins below, indicate which of the follow- ing processes each vitamin is involved in as a cofactor: (1) glycolysis, (2) gluconeogenesis, (3) lactate fermenta- tion, or (4) glycogenolysis. For a given vitamin, there may be more than one correct response, or only one or none of the responses may apply. a. Niacin b. Biotin c. Folate d. Vitamin B₁2

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describe the development of lactose intolerance from child age to adult age. also describe the detailed mechanism and molecular and enzymatic pathway related to development of lactose intolerance.

Answer 2

Question

Chapter 12, Problem 12.8PS

(a)

Summary Introduction

To determine: Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(b)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of degradation products in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(c)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of excessive amounts of glycogen in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(d)

Summary Introduction

To determine: Whether the given statement, “Results from an inability to regulate the synthesis of glycosaminoglycans” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(e)

Summary Introduction

To determine: Whether the given statement, “Results from an absence of functional acid hydrolases” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(f)

Summary Introduction

To determine: Whether the given statement, “Results in accumulation of lysosomes in the cell” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(g)

Summary Introduction

To determine: Whether the given statement, “Symptoms include muscle weakness and mental retardation” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(h)

Summary Introduction

To determine: Whether the given statement, “Triggers proliferation of organelles containing catalase” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

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Answer 3

Question

Chapter 12, Problem 12.8PS

(a)

Summary Introduction

To determine: Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(b)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of degradation products in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(c)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of excessive amounts of glycogen in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(d)

Summary Introduction

To determine: Whether the given statement, “Results from an inability to regulate the synthesis of glycosaminoglycans” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(e)

Summary Introduction

To determine: Whether the given statement, “Results from an absence of functional acid hydrolases” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(f)

Summary Introduction

To determine: Whether the given statement, “Results in accumulation of lysosomes in the cell” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(g)

Summary Introduction

To determine: Whether the given statement, “Symptoms include muscle weakness and mental retardation” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(h)

Summary Introduction

To determine: Whether the given statement, “Triggers proliferation of organelles containing catalase” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

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Answer 4

Question

Chapter 12, Problem 12.8PS

(a)

Summary Introduction

To determine: Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(b)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of degradation products in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(c)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of excessive amounts of glycogen in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(d)

Summary Introduction

To determine: Whether the given statement, “Results from an inability to regulate the synthesis of glycosaminoglycans” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(e)

Summary Introduction

To determine: Whether the given statement, “Results from an absence of functional acid hydrolases” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(f)

Summary Introduction

To determine: Whether the given statement, “Results in accumulation of lysosomes in the cell” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(g)

Summary Introduction

To determine: Whether the given statement, “Symptoms include muscle weakness and mental retardation” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(h)

Summary Introduction

To determine: Whether the given statement, “Triggers proliferation of organelles containing catalase” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

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Answer 5

Chapter 12, Problem 12.8PS

(a)

Summary Introduction

To determine: Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(b)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of degradation products in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(c)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of excessive amounts of glycogen in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(d)

Summary Introduction

To determine: Whether the given statement, “Results from an inability to regulate the synthesis of glycosaminoglycans” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(e)

Summary Introduction

To determine: Whether the given statement, “Results from an absence of functional acid hydrolases” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(f)

Summary Introduction

To determine: Whether the given statement, “Results in accumulation of lysosomes in the cell” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(g)

Summary Introduction

To determine: Whether the given statement, “Symptoms include muscle weakness and mental retardation” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

(h)

Summary Introduction

To determine: Whether the given statement, “Triggers proliferation of organelles containing catalase” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 6

Chapter 12, Problem 12.8PS

(a)

Summary Introduction

To determine: Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 7

Chapter 12, Problem 12.8PS

(a)

Summary Introduction

To determine: Whether the given statement, “Impaired metabolism of glycolipids that causes mental deterioration” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 8

(b)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of degradation products in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 9

(b)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of degradation products in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 10

(c)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of excessive amounts of glycogen in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 11

(c)

Summary Introduction

To determine: Whether the given statement, “Leads to accumulation of excessive amounts of glycogen in the lysosome” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 12

(d)

Summary Introduction

To determine: Whether the given statement, “Results from an inability to regulate the synthesis of glycosaminoglycans” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 13

(d)

Summary Introduction

To determine: Whether the given statement, “Results from an inability to regulate the synthesis of glycosaminoglycans” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 14

(e)

Summary Introduction

To determine: Whether the given statement, “Results from an absence of functional acid hydrolases” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 15

(e)

Summary Introduction

To determine: Whether the given statement, “Results from an absence of functional acid hydrolases” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 16

(f)

Summary Introduction

To determine: Whether the given statement, “Results in accumulation of lysosomes in the cell” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 17

(f)

Summary Introduction

To determine: Whether the given statement, “Results in accumulation of lysosomes in the cell” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 18

(g)

Summary Introduction

To determine: Whether the given statement, “Symptoms include muscle weakness and mental retardation” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 19

(g)

Summary Introduction

To determine: Whether the given statement, “Symptoms include muscle weakness and mental retardation” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 20

(h)

Summary Introduction

To determine: Whether the given statement, “Triggers proliferation of organelles containing catalase” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 21

(h)

Summary Introduction

To determine: Whether the given statement, “Triggers proliferation of organelles containing catalase” is common to most lysosomal storage diseases (M), true of a specific lysosomal storage disease (S), or not true of any lysosomal storage diseases (N).

Introduction: Accumulation of metabolites such as polysaccharides or lipids in the lysosomes causes lysosomal diseases. Deficiency of certain proteins, as well as enzymes, causes the accumulation of these metabolites. Defects in proteins essential for transportation of degradation products leads to accumulation of degraded products in the lysosomes. Most lysosomal storage diseases are fatal.

Answer 22

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Ch. 12 - How do differences in the structure and...Ch. 12 - Why is it necessary for material flowing through...Ch. 12 - What problems would you likely see in cells...Ch. 12 - What features of membrane lipids and proteins...Ch. 12 - Based on what you learned in this chapter about...Ch. 12 - How would an inhibitor of membrane fusion...Ch. 12 - What intracellular transport processes would you...Ch. 12 - What problems would a cell have if it could not...Ch. 12 - Although the plant vacuole resembles the lysosome...Ch. 12 - Why is it important for the biochemical reactions...

Solution Summary: The author explains that accumulating polysaccharides or lipids in the lysosomes causes mental deterioration, and deficiency in proteins essential for transportation of degradation products leads to accumulation of

Chapter 12 Solutions