Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
expand_more
expand_more
format_list_bulleted
Concept explainers
Videos
Textbook Question
Chapter 12, Problem 12.3CC
What problems would you likely see in cells defective in ER glycosylation of proteins?
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solution
Students have asked these similar questions
It is important to note that galactose is an important component of glyco-
proteins. What is the effect on glycoprotein synthesis in case of galactosemic
patients who are not given galactose in their diet? Explain this observation.
. The following diagram shows the biosynthesis of B12 coenzymes,
starting with the vitamin. DMB is dimethylbenzimidazole.
(a) What one additional substrate or cofactor is required by enzyme B?
(b) Genetic deficiency in animals of enzyme C would result in exces-
sive urinary excretion of what compound?
Starting from glutamine, glycine, aspartate, N 10-formyi-THF, how many ATP- equivalents are required for purine nucleotide synthesis?
2
8
4
6
Chapter 12 Solutions
Becker's World of the Cell (9th Edition)
Ch. 12 - How do differences in the structure and...Ch. 12 - Why is it necessary for material flowing through...Ch. 12 - What problems would you likely see in cells...Ch. 12 - What features of membrane lipids and proteins...Ch. 12 - Based on what you learned in this chapter about...Ch. 12 - How would an inhibitor of membrane fusion...Ch. 12 - What intracellular transport processes would you...Ch. 12 - What problems would a cell have if it could not...Ch. 12 - Although the plant vacuole resembles the lysosome...Ch. 12 - Why is it important for the biochemical reactions...
Ch. 12 - Compartmentalization of Function. Each of the...Ch. 12 - Endoplasmic Reticulum. For each of the following...Ch. 12 - Biosynthesis of Integral Membrane Proteins. In...Ch. 12 - Coated Vesicles in Intracellular Transport. For...Ch. 12 - QUANTITATIVE Interpreting Data. Each of the...Ch. 12 - Cellular Digestion. For each of the following...Ch. 12 - QUANTITATIVE Virus Entry by Endocytosis....Ch. 12 - Prob. 12.8PSCh. 12 - Sorting Proteins. Specific structural features tag...Ch. 12 - Prob. 12.10PSCh. 12 - Whats Happening? Researchers have discovered a...
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- When performing his experiments on protein refolding, Christian Anfinsen obtained a quite different result when reduced ribonuclease was reoxidized while it was still in 8 M urea and the preparation was then dialyzed to remove the urea. Ribonuclease reoxidized in this way had only 1% of the enzymatic activity of the native protein. Why were the outcomes so different when reduced ribonuclease was reoxidized in the presence and absence of urea?arrow_forwardWhat is meant by the term "sugar code"? What are the challenges in the field of glyco-biology?arrow_forwardWhich statement correctly explains the protonation states of these histidine residues? O His side chains predominantly exist in their deprotonated form, since biological pH is lower than the pKa of the His side chains. His side chains predominantly exist in their protonated form, since the pK, of the His side chains is lower than biological pH. O His side chains predominantly exist in their deprotonated form, since the pK of the His side chains is lower than biological pH. His side chains are deprotonated in the figure, but they will predominantly exist in their protonated form at biolog pH.arrow_forward
- Modify the structures of D-glucose and D-mannose to show a-D-glucosyl-(1→6)-D-mannosamine. H с H2C ОН с Н ОН Ni/ с ОН Н C I ОН Н 0 Н с CH₂ ОН Н ОН NM! с ジミ Н NH₂ ОН C | Н Carrow_forwardb) Why might the compound shown below act as a transition state analog of phosphoglucose isomerase? A drawing of the normal transition state for this enzyme is needed. HO- OH T .N -OH -OH CH₂OPO₂²-arrow_forwardIllustrate and explain the difference between α-D-glucopyranose and β-D-glucopyranose structures.arrow_forward
- The compound below, doxorubicin, is a substrate for p-glycoprotein. Cancer cells with a higher expression of P-gp (more P-gp protein per cell) than normal cells were treated with doxorubicin. What would be the expected observation? o= 0= OH O OH HCI OH -OH NH₂ & OH more doxorubicin inside the cell doxorubicin would be oxidized doxorubicin would have more cytotoxic effect on these cancer cells less doxorubicin inside the cellarrow_forwardConsider the Haworth projections of f-L-galactose and B-L-glucose shown here. ОН CH OH ОН ОН B-L-galactose enantiomers anomers OH diastereomers epimers ОН CH₂OH OH Which terms describe the relationship between these two sugars? ОН OH B-L-glucosearrow_forwardIdentify each reaction catalyzed by (a) a nucdeotidase; (b) a phosphorylase; (c) a phosphoribosyltransferase. GMP A D E Guanine Guanosine Farrow_forward
- Proteins have a high thermodynamic instability. Despite the fact that the G of protein hydrolysis is fairly negative, proteins may be quite stable. Explain the seeming contradiction. What does this mean in terms of protein synthesis?arrow_forwardо 6. What is the catalytic triad and what particular protein family would you find this? What is the general role of the catalytic triad? Predict what would happen if Asp were mutated to Gly. ructure formation of alpha heliarrow_forwardIf the substrate for an enzyme catalyzed reaction contained a negative charge, which of the following amino acids would most likely be present in the active site to provide electrostatic destabilization of the ES complex? Leu Val O Asp O LYS QUESTION 15 What is the function of the histidine in the diagram of the mechanism at right with the substrate, a phenylalanine residue? (n) His Asp Nucleophilic affack by water stabilization of a metal ion covalent catalysis electrostatic attraction of the substrate O acid base catalysis 789 Mustly cloudy Click Save and Submit to save and submit. Click Save All Ansuwers to save all answers. here to searcharrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
BiochemistryBiochemistryISBN:9781305577206Author:Reginald H. Garrett, Charles M. GrishamPublisher:Cengage Learning
Biochemistry
Biochemistry
ISBN:9781305577206
Author:Reginald H. Garrett, Charles M. Grisham
Publisher:Cengage Learning
Biomolecules - Protein - Amino acids; Author: Tutorials Point (India) Ltd.;https://www.youtube.com/watch?v=ySNVPDHJ0ek;License: Standard YouTube License, CC-BY