Study Guide for Campbell Biology
11th Edition
ISBN: 9780134443775
Author: Lisa A. Urry, Michael L. Cain, Steven A. Wasserman, Peter V. Minorsky, Jane B. Reece, Martha R. Taylor, Michael A. Pollock
Publisher: PEARSON
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Chapter 11, Problem 7IQ
Summary Introduction
To review: The appropriate G-protein coupled pathway that uses Ca2+ as a secondary messenger.
Introduction: G-protein coupled receptor (GPCR) is also known as “seven transmemebrane domain receptor”. They are the largest family of cell surface receptors. It binds to various ligands such as neurotransmitters, peptide hormones and odor molecules. GPCR are involved in many cellular processes.
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Students have asked these similar questions
A hormone signals through a G protein-coupled receptor as shown in the diagram. After the production of IP3, which of these events will MOST quickly stop the transduction of the signal?
A. the hydrolysis of IP3
B. the hydrolysis of GTP
C. the hydrolysis of PIP2
D. the hydrolysis of the hormone
I believe the answer is (B) the hydrolysisof GTP, because the G protein becomes inactive after GTP is hydrolyzed to GDP. However, the solution provided by Bartleby is (C). Please explain. Thanks
Which of the following would be considered second messengers of a signaling pathway?
Select one:
a. A kinase enzyme
b. A scaffolding protein holding three kinases
c. Adenyl cyclase
d. All answers are examples of second messengers
e. A sugar like inositol
f. Ligand gated channel
What features are remarkable about steroid receptors? (Select all that apply)
A. Steroid receptors are localized in the cytoplasm
B. steroid receptors are localized in the plasma membrane
C. steroid receptors can translocate to the nucleus
D. steroid receptors represent the beginning of a signaling Cascade
E. steroid receptors can also function as transcription factors
Chapter 11 Solutions
Study Guide for Campbell Biology
Ch. 11 - How do plant hormones (often called plant growth...Ch. 11 - Prob. 2IQCh. 11 - Label the parts in the following diagram of an...Ch. 11 - Prob. 4IQCh. 11 - a. What does a protein kinase do? b. What is a...Ch. 11 - Prob. 6IQCh. 11 - Prob. 7IQCh. 11 - Prob. 8IQCh. 11 - a. What can one conclude from the fact that the...Ch. 11 - Prob. 1SYK
Ch. 11 - Briefly describe the three stages of cell...Ch. 11 - Some signaling pathways alter a proteins activity;...Ch. 11 - Prob. 4SYKCh. 11 - Prob. 1TYKCh. 11 - Steroid hormones a. bind to cell-surface...Ch. 11 - Prob. 3TYKCh. 11 - Prob. 4TYKCh. 11 - Which of the following is a key difference between...Ch. 11 - Many human diseases (including bacterial...Ch. 11 - Prob. 7TYKCh. 11 - If a protein is activated by the addition of a...Ch. 11 - Prob. 9TYKCh. 11 - Prob. 10TYKCh. 11 - From studying the effects of epinephrine on liver...Ch. 11 - You are a Ca2+ ion in a typical animal cell. Where...Ch. 11 - Which of the following molecules is incorrectly...Ch. 11 - Prob. 14TYKCh. 11 - Prob. 15TYK
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- a universal feature of cell signaling receptors is that they? a. undergo a structural (shape) change when the signal molecule is bound b. are present only in the plasma membrane c. are only ion channels d. are protein kinases e. aer only nuclear receptorsarrow_forwardA hormone signals through a G protein-coupled receptor as shown in the diagram. After the production of IP3, which of these events will MOST quickly stop the transduction of the signal? A. the hydrolysis of IP3 B. the hydrolysis of GTP C. the hydrolysis of PIP2 D. the hydrolysis of the hormonearrow_forwardA hormone signals through a G protein- coupled receptor as shown in the diagram. After the production of IP3, which of these events will MOST quickly stop the transduction of the signal? A. the hydrolysis of IP3 B. the hydrolysis of GTP C. the hydrolysis of PIP2 D. the hydrolysis of the hormonearrow_forward
- The activation of receptor tyrosine kinases is characterized by a. dimerization and phosphorylation b. a phosphorylation cascade c. channel protein shape change d. GTP hydrolysisarrow_forwardWhich of the following enzymes does NOT catalyzes the formation a second messenger? A. PI3K B. Protein kinase C C. Phospholipase C D. Guanylyl cyclase Which of the following statements is correct? A. Lipolysis is inhibited by epinephrine and glucagon B. Phosphorylation of triacylglycerol lipase inhibits its activity C. Activation of protein kinase A inhibits lipolysis D. Fatty acids are activated in mitochondria before undergoing b-oxidation E. Lipolysis is stimulated by cAMP F. None of the abovearrow_forward2) Indicate by writing “yes” or “no” whether amplification of a signal could occur at the particular steps described below. Explain your answers. A. B. C. D. E. An extracellular signaling molecule binds and activates a GPCR. The activated GPCRs cause Ga to separate from GB and Gy. Adenylyl cyclase produces cyclic AMP. CAMP activates protein kinase A. Protein kinase A phosphorylates target proteins.arrow_forward
- What is a key characteristics of a G protein-linked receptors? a. it allows ions to flow through b. it changes confirmation and becomes autophosporylated c. it is a serpentine transmembrane receptor?arrow_forwardTAS2R38 codes for a G-protein coupled receptor which contributes to the tasting of PTC. What does this tell you about PTC as a type of ligand? a It is a protein-based ligand that can cross the CM into the cell b It is a lipid based ligand that can cross the CM into the cell c It is a protein-based ligand that requires a second messenger d It is a lipid-based ligand that requires a second messengerarrow_forwardThis is a tyrosine kinase receptor. a. Briefly describe the action of the receptor upon binding to the logand. b. There are several intracellular pathway possibilities for downstream responses. How might this receptor be able to selectively activate one particular pathway over another?arrow_forward
- A biochemist is designing a new drug that will mimic the shape and function of a particular intercellular signaling molecule. Therefore she must produce a molecule that will bind to the receptor protein and... A. produce a cellular response by altering the Na+/K+ pump located near the receptor site. B. induce a change in the receptor molecule shape, which will ultimately prevent a cellular response. C. induce a change in the receptor molecule shape, which will ultimately produce a cellular response. D. induce a change in the phospholipid bilayer that causes a polar reversal allowing the molecules to be endocytose (engulfed).arrow_forwardIdentify which of the following statements is a lie? Select one: a. The docking of ligands to the receptor causes receptor-associated proteins to activate another protein to continue the signaling cascade and one example of this event is the binding of epidermal growth factor (EGF) to the EGF receptor . b. Ligands are important to initiate signal Transduction pathway. c. Ligands detach from the cell surface receptor in order to change the conformation of the receptor and initiate the signaling pathway.arrow_forwardWhich is correct?a. cAMP-dependent protein kinase phosphorylates tyrosine residues.b. Protein kinase C is activated by cAMP.c. The subunit of Gs proteins that activates adenylyl cyclase is the beta subunit.d. Lipid-soluble messengers typically act on receptors in the cell cytosol ornucleus.e.The binding site of a typical plasma membrane receptor for its messenger is located on the cytosolic surface of the receptor.arrow_forward
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Intro to Cell Signaling; Author: Amoeba Sisters;https://www.youtube.com/watch?v=-dbRterutHY;License: Standard youtube license