Genetic Analysis: An Integrated Approach (3rd Edition)
3rd Edition
ISBN: 9780134605173
Author: Mark F. Sanders, John L. Bowman
Publisher: PEARSON
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Textbook Question
Chapter 11, Problem 26P
During mismatch repair, why is it necessary to distinguish between the template strand and the newly made daughter strand? Describe how this is accomplished.
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Students have asked these similar questions
Explain how mismatch repair fixes incorrectly matched base pairs.
During mismatch repair, why is it necessary to distinguish betweenthe template strand and the newly made daughter strand? How isthis accomplished?
What is/are the attributes that make nucleotide excision repair (NER) and base excision repair (BER)
similar and/or different from each other?
Select the correct response:
The NER pathway is the only one that can remove DNA lesions in the strand regardless of
their size which is followed by attaching the correct strand, then sealed by a DNA ligase.
They both use the enzyme DNA glycosylases that recognizes the damaged DNA segments
and proceed with repairing the faulty base in the strand. They differ NER only repairs purine
bases while BER repairs pyrimidine bases.
They both remove the damaged parts of the DNA where the BER pathway corrects only the
identified damaged bases which are usually non-bulky lesions. The NER pathway, on the
other hand, repairs the damage by removal of bulky DNA adducts which is a short-single
stranded DNA segment.
They both utilize the enzyme photolyase to reverse the damages created by the faulty section
of the DNA.
They both remove the damaged parts of the…
Chapter 11 Solutions
Genetic Analysis: An Integrated Approach (3rd Edition)
Ch. 11 - 11.1 Identify two general ways chemical mutagens...Ch. 11 - 11.2 Nitrous acid and (BU) alter DNA by different...Ch. 11 - 11.3 What is the difference between a transition...Ch. 11 - What is the difference between a synonymous...Ch. 11 - 11.5 UV irradiation causes damage to bacterial...Ch. 11 - Ultraviolet (UV) radiation is mutagenic.
What...Ch. 11 - Researchers interested in studying mutation and...Ch. 11 - The effect of base - pair substitution mutations...Ch. 11 - Describe the purpose of the Ames test. How are...Ch. 11 - 11.10 In numerous population studies of...
Ch. 11 - 11.11 Two different mutations are identified in a...Ch. 11 - What is the phenotype effect of inserting a Ds...Ch. 11 - 11.13 Answer the following questions concerning...Ch. 11 - Several types of mutation are identified and...Ch. 11 - 11.15 A sample of the bacterium is exposed to...Ch. 11 - 11.16 A strain of is identified as having a null...Ch. 11 - Describe the difference between DNA transposons...Ch. 11 - 11.18 How are flanking direct repeat sequences...Ch. 11 - 11.19 Using the adeninethymine base pair in this...Ch. 11 - The partial amino acid sequence of a wild-type...Ch. 11 - Prob. 21PCh. 11 - 11.22 Many human genes are known to have homologs...Ch. 11 - The fluctuation test performed by Luria and...Ch. 11 - In this chapter, three features of genes or of DNA...Ch. 11 - Briefly compare the production of DNA double -...Ch. 11 - During mismatch repair, why is it necessary to...Ch. 11 - 11.27 Following the spill of a mixture of...Ch. 11 - 11.28 In an Ames test using Salmonella bacteria a...Ch. 11 - A wild - type culture of haploid yeast is exposed...Ch. 11 - A fragment of a wild - type polypeptide is...Ch. 11 - Prob. 31PCh. 11 - Alkaptonuria is a human autosomal recessive...Ch. 11 - 11.33 In an experiment employing the methods of...Ch. 11 - Using your knowledge of DNA repair pathways choose...Ch. 11 - 11.35 Ataxia telangiectasia is a human inherited...Ch. 11 - A geneticist searching for mutations uses the...Ch. 11 - 11.37 In a mousebreeding experiment a new mutation...Ch. 11 - 11.38 Considering the Dumbo mutation in a Problem,...Ch. 11 - 11.39 Thinking back to the discussion of...Ch. 11 - 11.40 Common baker’s yeast () is normally grown at...Ch. 11 - 11.41 The two gels illustrated below contain...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- In the scenario where a single strand break occurs in the DNA replication fork: a) What would happen if RecC failed to bind to the chi site? Explain briefly and draw out the step at which recombinational DNA repair would stall. b) What would happen if RecA failed to bind DNA? Explain briefly and draw out the step at which recombinational DNA repair would stall. c) Draw the resolved product of this Holliday junction if it's cleaved in the direction of the white triangles. Is the result a heteroplex or recombinant? A Strand Invasion Ⓒ Holliday Junction A Resolvearrow_forwardWhat is an advantage and a disadvantage of this repair system?arrow_forwardThere are two types of excision repair, base excision repair (BER) and nucleotide excision repair (NER). Which enzymes are used in Base excision repair in E. coli?And In nucleotide excision repair, what kind of damage is repaired by this mechanism and why are cutsmade on both sides of the damaged region of DNA?arrow_forward
- What is the significance of DNA methylation in mismatch repair?arrow_forwardWhen the mismatch repair system detects a distortion in the DNA double helix due to a mismatch, what mechanism ensures that the base on the parental strand is preserved and the base on the recently replicated strand is corrected.arrow_forwardExplain whether mismatch repair reduce the replication error if it is repaired without regard for which strand served as template.arrow_forward
- For the following situations, indicate whether homologous or non-homologous DNA strands are preferred to use as template: Prokaryotic double strand break repair: Mitotic double strand break repair: Meiotic double strand break repair:arrow_forwardExplain how methyl-directed mismatch repair candistinguish which strand to repair when replicationerrors occur.arrow_forwardDuring the process of transcription, the polymerase must handle several distinct polynucleotide chains: the double-stranded DNA ahead of the polymerase, the single-stranded template DNA, the nontemplate DNA strand, and the freshly-synthesized mRNA. How does the polymerase keep each of these strands--as well as the incoming ribonucleotides needed for the polymerase reaction--separate?arrow_forward
- Describe the excision repair process in DNA, using the excision of thymine dimers as an example.arrow_forwarda) Within Region 1, which strand will be the template for leading strand synthesis, the top or the bottom? Whyarrow_forwardWhat enzymatic features of DNA polymerase prevent it from replicating one of the DNA strands at the ends of linear chromosomes? Compared with DNA polymerase, how is telomerase different in its ability to synthesize a DNA strand? What does telomerase use as its template for the synthesis of a DNA strand? How does the use of this template result in a telomere sequence that is tandemly repetitive?arrow_forward
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