Essentials of Genetics (9th Edition) - Standalone book
Essentials of Genetics (9th Edition) - Standalone book
9th Edition
ISBN: 9780134047799
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino
Publisher: PEARSON
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Chapter 10, Problem 13PDQ
Summary Introduction

To review:

The function of the ten subunits of deoxyribonucleic acid (DNA) polymerase III and differences between holoenzyme and the core enzyme.

Introduction:

DNA polymerase III is the primary enzyme complex involved in DNA replication of both leading as well as lagging strand in prokaryotes like Escherichia coli (E. coli). It is a holoenzyme that contains ten subunits. All these subunits have their own specific functions.

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Describe the function of DNA polymerase. Explain why each part of the name DNA polymerase (DNA, polymer, -ase) makes sense.
Explain the molecular mechanism of DNA polymerization by DNA polymerase and explain why DNA polymerase 3 and not dna polymerase 1 is responsible for replicating the bacterial genome.
Explain why two metal ions play important role on the palm domain of DNA polymerase.
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