Becker's World of the Cell (9th Edition)
Becker's World of the Cell (9th Edition)
9th Edition
ISBN: 9780321934925
Author: Jeff Hardin, Gregory Paul Bertoni
Publisher: PEARSON
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Chapter 10, Problem 10.8PS

Regulation of Catabolism. Explain the advantage to the cell of each of the following regulatory mechanisms.

  1. (a) Isocitrate dehydrogenase (Figure 10-9, reaction CAC-3) is allosterically activated by ADP.
  2. (b) The dehydrogenases that oxidize isocitrate, α-ketoglutarate, and malate (reactions CAC-3, CAC-4, and CAC-8) are all allosterically inhibited by NADH.
  3. (c) Pyruvate dehydrogenase (Figure 10-9, Reaction 10-1) is allosterically inhibited by ATP.
  4. (d) Phosphofructokinase (Figure 9-13, reaction Gly-3) is allosterically inhibited by citrate.
  5. (e) Pyruvate dehydrogenase kinase (Figure 10-11, enzyme E1) is allosterically activated by NADH.
  6. (f) α-ketoglutarate dehydrogenase (Figure 10-11, reaction CAC-4) is allosterically inhibited by succinyl CoA.
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