Chapter 10, Problem 10.3PS

True or False. Indicate whether each of the following statements is true (T) or false (F). If false, reword the statement to make it true.

1. (a) The orderly flow of carbon through the citric acid cycle is possible because each of the enzymes of the cycle is embedded in the inner mitochondrial membrane in such a manner that their order in the membrane is the same as their sequence in the cycle.
2. (b) Thermodynamically, acetyl CoA should be capable of driving the phosphorylation of ADP (or GDP), just as succinyl CoA does, assuming availability of the appropriate enzyme.
3. (c) Respiration is impossible without oxygen as an electron acceptor for the reoxidation of coenzymes.
4. (d) We can predict that the flow of electrons through the electron transport system is exergonic because the NAD⁺/NADH redox pair has a highly negative ΔE₀′ and the O₂/H₂O redox pair has a highly positive ΔE₀′.
5. (e) Unlike NAD⁺, the coenzyme FAD tends to be tightly associated with the dehydrogenase enzymes that use it as an electron acceptor.
6. (f) Because β oxidation degrades fatty acids in two-carbon acetyl CoA units, it is not possible to degrade fatty acids with an odd number of carbons.