Introduction to Genetic Analysis
Introduction to Genetic Analysis
11th Edition
ISBN: 9781464109485
Author: Anthony J.F. Griffiths, Susan R. Wessler, Sean B. Carroll, John Doebley
Publisher: W. H. Freeman
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Chapter 1, Problem 16P

a.

Summary Introduction

To determine: The maximum amount of mutation that can be seen in the male chromosomes.

Introduction: The two types of sexes, males and females possess different sexual characteristics due to the presence of their sexual hormones along with the different sex chromosomes. The male shows heterogamety, whereas the female shows homogametic nature.

b.

Summary Introduction

To determine: The least number of mutations on which chromosome.

Introduction: The cells that are to be inherited undergo the process of meiosis in which there occurs the reduction of chromosome number to half.

c.

Summary Introduction

To determine: The new mutation rate per base pair on the X and Y chromosome.

Introduction: The male possesses the heterogametic nature, whereas the females possess the homogametic nature. Males have X and Y chromosomes, whereas females have a pair of X chromosomes.

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A scientist investigating the genome of two related individuals observes a difference of a few nucleotides in one individual compared to the other. The nucleotide differences are in a region of noncoding DNA on chromosome 1. Would these differences be considered a mutation? Why or why not? Yes, the difference in nucleotide sequences between the individuals is a mutation because it will affect the phenotype of the two individuals. Yes, any heritable variation in the nucleotide sequence is considered a mutation, even if that variation is in a noncoding region of DNA. Not enough information was provided to determine if this nucleotide difference is a mutation because the effect on phenotype is unknown. No, the change in nucleotide sequence doesn't appear in a coding region of the DNA and so can't be a mutation.
In a college genetics laboratory course, a healthy student constructs a karyotype from a cell from inside her cheek. She finds only one chromosome 3 and one chromosome 21, plus two unusual chromosomes that do not seem to have matching partners. a. What type of chromosomal abnormality does she have? b. Why doesn’t she have any symptoms? c. Would you expect any of her relatives to have particular medical problems?
The homologous chromosome pairs in our cells do not carry identical sequences in all loci. This heterozygosity (difference between the two.copies) can be altered in cancer: in fact, loss of heterozygosity at many loci is observed in cancer cells, through an increase in either homozygosity (two identical copies) or hemizygosity (i.e. loss of one copy). Researchers can take advantage of this loss of heterozygosity in cancer cells to identify genomic loci that contain cancer-critical genes. What type of gene would you expect to find in chromosomal regions with a loss of heterozygosity? Proto-oncogenes or tumour suppressor genes? Choose the correct answer here Proto-oncogenes Tumour Suppressor genes
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Mitochondrial mutations; Author: Useful Genetics;https://www.youtube.com/watch?v=GvgXe-3RJeU;License: CC-BY