Why is it advantageous for p53 to be activated by factors such as ER stress, light, and hypoxia (low oxygen concentration)?

Q: Describe how the signal transduction pathway leads to activation of MAPKinase or Akt/PKB?

A: Answer: Introduction: Signal transduction is the mechanism by that a biochemical or physical signal…

Q: Describe the nature of p53 reactivation as acancer-fighting strategy

A: Cancer is a condition that arises due to uncontrolled cell division.

Q: Describe the general process of cell signalling pathways: what events take place for a signal to…

A: * mainly there are Three Stages of Cell Signaling . The first one is reception and here the signal…

Q: ne epidermal growth factor receptor (EGFR) activates a complex signaling network - increase…

A: The example shown in the question shows the ligand binding and the cascading of effects that is…

Q: Metabolic syndrome is a clustering of various conditions including high blood pressure, high blood…

A: Metabolic syndrome is a group of disorders that occur in tandem and increase your risk of heart…

Q: Explain why in cells that are genetically NF1–/–, basal levels of GTP-bound activated Ras are higher…

A: Neurofibromatosis type 1 (NF1) is a typical hereditary problem portrayed by various neurofibromas,…

Q: How machinery of gene regulation is controlled by cell signaling?

A: Cell signaling is a process, during which extracellular ligand molecules get binds to the receptor…

Q: Activation of p53 during cellular stress will generally Select one: o a. Increase transcription of…

A: P553 is a tumor suppressor gene.

Q: The epidermal growth factor receptor (EGFR) activates a complex signaling network to increase…

A: Answer  C-myc synthesis is responsible for cell growth and development and prevent apoptosis.…

Q: Predict the effects of the following mutations on the ability of a cell to undergo apoptosis:a.…

A: KEY WORDS :- Mutations - Structure or the process of gene is changed or have any effect which can…

Q: what would be the likely effect of a mutation that prevented the formation of memory cells?

A: Mutation is the sudden heritable changes that occur in the DNA sequences due to error while copying…

Q: RAS is a signal transducer that acts as a switch for turning on cell division. Drag the descriptions…

A: Cells communicate with each other through specific chemical signaling pathways that are known as…

Q: How does constitutively active Ras promote cancer?

A: In physiology carcinogenesis is known as the production of cancerous cells or tumor cells by…

Q: A mutated form of protein p5x is found in patients with squamous cell carcinoma. In vitro studies…

A: A gene that produces a protein that is essential for regulating cell division and death and is…

Q: Describe the ATM-p53 repair pathway in normal cells and cancerous cells

A: Apoptosis is a genetically controlled mechanism of cell death, which is important for the…

Q: Explain the use of cyclins and cyclin-dependent kinases(CDKs) ?

A: Cyclins are cellular elements that drive or regulate the events of the cell cycle by combining with…

Q: What purpose do scaffolding proteins serve in binding to Map kinase enzymes?

A: Introduction :- MAPKs are serine/threonine kinases that activate a variety of cytoplasmic and…

Q: Why is it advantageous for p53 to be activated by factorssuch as ER stress, UV light, and hypoxia…

A: The p53 is known as tumor protein formed from the TP53 gene. The protein acts as a tumor suppressor…

Q: Explain how hematopoietic stem cells were experimentally shown to be both multipotent and capable of…

A: Answer: Introduction: Hematopoietic stem cells (HSCs) are multipotent, self-renewing progenitor…

Q: ulate the cell cycle called tumar supressors

A: Tumor suppressor genes can be defined as the normal genes that affect the process of cell division…

Q: What do you mean by S-phase cyclindependent kinases?

A: Cyclin-dependent kinases (Cdk) are a family of serine/threonine protein kinases. Cdks play a…

Q: You've engineered a mutant cell where the FADD adapter was truncated. The mutant FADD only contains…

A: The process of programmed cell death is called apoptosis. Unwanted cells, such as those between a…

Q: Why is the p53-meditated apoptosis pathway, and the GSK3 signaling pathway important for cancer…

A: p53 is a critical tumour suppressor that is mutated in ~50% of human cancers. Inunstressed cells p53…

Q: // Which CDK and cyclin does p53 ultimately target in DNA damaged conditions? O CDK1/cyclin E O…

A: CDK phosphorylate soecific target proteins. They required cyclin to be activate. CDK-cyclin…

Q: What is the process for retrieving soluble, luminal ER proteins that "leak" out of into the…

A: Endoplasmic reticulum (ER) is an organelle present in eukaryotic cells that is in charge of protein…

Q: p53 is an important DNA damage checkpoint protein that stops the transition to S phase and is lost…

A: p53, also known as TP53 or tumor protein (EC :2.7. 1.37) is a gene that codes for a protein that…

Q: Explain why p53 is mutated in the vast majority of human cancers.

A: Any isoform of a protein encoded by homologous genes in multiple animals, such as TP53 and Trp53, is…

Q: Compare and contrast the intrinsic and extrinsic apoptosis pathways. Please keep brief - 3…

A: Apoptosis is an energy-dependent process of programmed cell death. It occurs normally during…

Q: How do studies of brain development in knockout mice support the statement that apoptosis is a…

A: Apotopsis is a process of programmed cell death. It is a process in which the cell division is…

Q: As a cancer researcher, which segment of the signal transduction pathway would you target to prevent…

A: As a cancer researcher, targeting the signal transduction pathway can be an effective approach to…

Q: Two mechanisms inducing Apoptosis, Extrinsic pathway and Intrinsic pathway, have difference and…

A:

Q: What occurs when the JAK-STAT pathway is activated?

A: The JAK/STAT pathway is a cell signaling pathway. The JAK are a category of proteins belonging to…

Q: ''In the cellular regulatory pathways that controlcell growth and proliferation, the products of…

A: Cell regulation involves a complex mechanism of different cell signaling pathways that work in a…

Q: Changes in the activity of a variety of Cdks are essential for accurate progression through the cell…

A: A series of events which takes place in a cell due to which it divides and forms two daughter cells…

Q: Signaling pathways often require receptor dimers to become active. What would be an advantage of the…

A: Most receptors dimerize during their association with their ligands. This dimerization provides them…

Q: Which of the following are true for the c-myc gene? Select all that apply

A: Myc is a group of regulator genes that code for transcription factors. c-myc is one of the genes in…

Q: Describe, in details, how acetylcholine signal molecule can trigger gene transcription via GPCR and…

A: Acetylcholine : It is the chief neurotransmitter of the parasympathetic nervous system , the part of…

Q: how is sustained proliferative signaling necessarry for cancer development and how is it a driving…

A: Cancer is when abnormal cells divide in an uncontrolled way.  Abnormalities are generally due to…

Q: You are analyzing the activity of the protein p53 in two different cell types. You notice that p53…

A: The function of a protein is primarily related to its structure if the composition of protein is…

Q: The p53 protein regulates the expression of BAX and Bcl2 to keep division at normal rate. Explain…

A: The p53 gene codes for p53 protein which regulates the expression of BAX and Bcl2 to keep cell…

Q: Metabolic syndrome is a clustering of various conditions including high blood pressure, high blood…

A: Satiety is feeling of fullness. Thus insulin causes satiety meaning that it induces the increasing…