p53 is an important DNA damage checkpoint protein that stops the transition to S phase and is lost in many cancers. Which of the following would mimic the loss of p53? Loss of Mdm2 Increase in transcription of p21 Mutating the Chk2 phosphosites of p53 to glutamic acid Mutating the Chk2 phosphosites of p53 to alanine Increase in Chk2 kinase activity

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Mary O'Keefe calls the Inner City Health Care office in a panic. Gwen Carr, CMA (AAMA), answers the telephone. Mary: "Oh my God, help me. I need Dr. King." Gwen: "This is Ellen Armstrong, Who is this calling? What is the situation?" Mary: "It's my haby, oh God, get Dr. King." Gwen: "Dr. King is unavailable, but we can help you. Now, tell me your name." Mary: "It's Mary O'Keefe. Help me, I think my baby is dead." Gwen: "Are you at home?" Mary: "Yes" Gwen: "Ok. Try to calm down. Speak slowly and tell me what's happened." Mary: "My son Chris pried the plug off an outlet and he's electrocuted himself!" Mary cries. "He's just lying there. I'm so scared, if I touch him, will I electrocute myself? Oh my God, my baby, my baby. What should I do?" Gwen, who has been writing down the details on a piece of paper, motions to Joe Guerrero, another CMA (AAMA) in the office, and hands him her notes. Joe immediately accesses the O'Keefe address from the patient database and uses…

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