p53 is an important DNA damage checkpoint protein that stops the transition to S phase and is lost in many cancers. Which of the following would mimic the loss of p53? Loss of Mdm2 Increase in transcription of p21 Mutating the Chk2 phosphosites of p53 to glutamic acid Mutating the Chk2 phosphosites of p53 to alanine Increase in Chk2 kinase activity

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