Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Explain why p53 is mutated in the vast majority of human cancers.
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- Mutations in p53 are commonly associated with malignant tumor formation. Do deleterious mutations in p53 usually lead to a loss of function or gain of function of the protein?arrow_forwardExplain how epigenetic changes can contribute to tumorigenesis.arrow_forwardList the regulatory mechanisms that might be lost in a cell producing faulty p53.arrow_forward
- The vast majority of human cancers mutations in the p53 gene. What is the function of p53 normally in the cell? What happens when p53 is mutated? Is this a gain of function or loss of function mutation?arrow_forwardExplain why it usually takes more than one mutation to cause cancerarrow_forwardThere are three broad categories of cancer-related genes: proto-oncogenes, tumor suppressor genes, and DNA stability/repair genes. Define each of these categories and indicate which one you think the RB1 gene belongs to and why.arrow_forward
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