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// Which one of these does CDK1/cyclin mitotic kinase NOT do to induce mitosis? Phosphorylates Histone H1 to condense chromosomes Phosphorylates pore proteins to disassemble pores Phosphorylates transcription factors to shut off transcription Phosphorylates lamins for lamin assembly

// Which one of these does CDK1/cyclin mitotic kinase NOT do to induce mitosis? Phosphorylates Histone H1 to condense chromosomes Phosphorylates pore proteins to disassemble pores Phosphorylates transcription factors to shut off transcription Phosphorylates lamins for lamin assembly

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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**Question:** Which **one** of these does CDK1/cyclin mitotic kinase NOT do to induce mitosis? 1. Phosphorylates Histone H1 to condense chromosomes 2. Phosphorylates pore proteins to disassemble pores 3. Phosphorylates transcription factors to shut off transcription 4. Phosphorylates lamins for lamin assembly This question is testing your knowledge of the specific actions of CDK1/cyclin mitotic kinase and its role in the regulation of mitosis. **Detailed Explanation:** CDK1 (Cyclin-dependent kinase 1), in association with cyclin, plays a vital role in the progression of cells through the cell cycle. During mitosis, CDK1/cyclin complexes have several key functions: 1. **Phosphorylates Histone H1 to condense chromosomes:** This action is crucial for chromatin condensation, which is necessary for the proper segregation of chromosomes during cell division. 2. **Phosphorylates pore proteins to disassemble pores:** This refers to the disassembly of the nuclear pore complexes, which is essential for nuclear envelope breakdown, allowing mitotic spindle access to chromosomes. 3. **Phosphorylates transcription factors to shut off transcription:** Shutting off transcription during mitosis ensures that resources are focused on cell division rather than gene expression. 4. **Phosphorylates lamins for lamin assembly:** This statement is incorrect because CDK1/cyclin actually phosphorylates lamins to disassemble the nuclear lamina, not for lamin assembly. Disassembly of the nuclear lamina is necessary for nuclear envelope breakdown during mitosis. Hence, the correct answer would be that CDK1/cyclin mitotic kinase does NOT phosphorylate lamins for lamin assembly to induce mitosis.
Transcribed Image Text:**Question:** Which **one** of these does CDK1/cyclin mitotic kinase NOT do to induce mitosis? 1. Phosphorylates Histone H1 to condense chromosomes 2. Phosphorylates pore proteins to disassemble pores 3. Phosphorylates transcription factors to shut off transcription 4. Phosphorylates lamins for lamin assembly This question is testing your knowledge of the specific actions of CDK1/cyclin mitotic kinase and its role in the regulation of mitosis. **Detailed Explanation:** CDK1 (Cyclin-dependent kinase 1), in association with cyclin, plays a vital role in the progression of cells through the cell cycle. During mitosis, CDK1/cyclin complexes have several key functions: 1. **Phosphorylates Histone H1 to condense chromosomes:** This action is crucial for chromatin condensation, which is necessary for the proper segregation of chromosomes during cell division. 2. **Phosphorylates pore proteins to disassemble pores:** This refers to the disassembly of the nuclear pore complexes, which is essential for nuclear envelope breakdown, allowing mitotic spindle access to chromosomes. 3. **Phosphorylates transcription factors to shut off transcription:** Shutting off transcription during mitosis ensures that resources are focused on cell division rather than gene expression. 4. **Phosphorylates lamins for lamin assembly:** This statement is incorrect because CDK1/cyclin actually phosphorylates lamins to disassemble the nuclear lamina, not for lamin assembly. Disassembly of the nuclear lamina is necessary for nuclear envelope breakdown during mitosis. Hence, the correct answer would be that CDK1/cyclin mitotic kinase does NOT phosphorylate lamins for lamin assembly to induce mitosis.
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