Oscillations in the activity of which protein family propels the cell cycle forward and creates abrupt transitions between different cell cycle states?
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Oscillations in the activity of which protein family propels the cell cycle forward and creates abrupt transitions between different cell cycle states?
- prophases
- kinetochores
- cyclin-dependent kinases
- microtubules
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Solved in 3 steps
- What composed of a regulatory cyclin subunit and a catalytic cyclin-dependent kinase (CDK) sub-unit, drive the progression of a cell through the cell cycle.Describe how cyclins and cyclin-dependent kinases are related. How do these molecules help regulate the cell cycle?What cellular mechanism(s) ensure that passage through the cell cycle is unidirectional and irreversible? What mo-lecular machinery underlies these mechanism(s)?
- Match these cell division phases with the appropriate processes Break down of the nuclear membrane [ Choose ] allowing mitotic spindles to connect to [Choose ] Telophase Metaphase Anaphase Prometaphase Cytokinesis Interphase kinetochores APC degrades securin which allows separase to become active which degrades the cohesin rings Dephosphorylation of nuclear pore and lamins cleavage of plasma membrane by actin and myosin contractile ring [ Choose ] copying of the genome [ Choose ] formation of the metaphase plate [Choose ]What promoting entry into the cell cycle are conserved across species. G1 CDKs inhibit a transcrip-tional repressor. This allows the transcription of G1/S phase cyclin genes and other genes important for S phase.Progression through the cell cycledepends on the phosphorylationof hundreds of different proteins bycyclin–Cdk complexes. What are themolecular mechanisms ensuring thatthese proteins are phosphorylated atprecisely the right time and place?
- Which subunits activate CDKs at different cellcycle stages. Cyclins are present only in the cell cycle stagesthat they promote.In mammalian cells, different cyclin-CDK complexes regulate progression of cells through the cell cycle. Which of the following would be true during the cell cycle? Select all that apply Cyclin D phosphorylates and activates MCM protein, a helicase Cyclin B phosphorylates and breaks down the nuclear lamina OThe anaphase promoting complex, or APC/C is phosphorylated and activated by cyclin B Cyclin D helps promotes passage through the restriction point// Which one of these does CDK1/cyclin mitotic kinase NOT do to induce mitosis? Phosphorylates Histone H1 to condense chromosomes Phosphorylates pore proteins to disassemble pores Phosphorylates transcription factors to shut off transcription Phosphorylates lamins for lamin assembly
- 28. 28. Which of the following would be expressed at approximately equal levels throughout the cell cycle? Kinetochore proteins Cyclins Cohesins Cyclin-dependent kinasesMitotic spindle function relies heavily on microtubule motors. For each of the following motor proteins, predict the effect on spindle formation, function, or both of adding a drug that specifically inhibits only that motor: kinesin-5, kinesin-13, and kinesin-4.Which of the following would result in cell cycle arrest? O phosphorylation of Rb by G1-Cdk phosphorylation of p53 O phosphorylation of helicase by S-Cdk phosphorylation of M-Cdk by CAK phosphorylation of APC by M-Cdk
