Indicate whether each of the following statements related is likely to be true or false Similar to the Cdks, when activated, the anaphase-promoting complex phosphorylates its targets. The level of M-cyclin is constant throughout the cell cycle

Indicate whether each of the following statements related is likely to be true or false Similar to the Cdks, when activated, the anaphase-promoting complex phosphorylates its targets. The level of M-cyclin is constant throughout the cell cycle

Biology: The Unity and Diversity of Life (MindTap Course List)

14th Edition

ISBN:9781305073951

Author:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Publisher:Cecie Starr, Ralph Taggart, Christine Evers, Lisa Starr

Chapter32: Neural Control

Section: Chapter Questions

Problem 12SQ: Neurons are arrested in ________ of the cell cycle. a. G1 b. anaphase c. prophase d. S phase

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Question

Indicate whether each of the following statements related is likely to be true or false

Similar to the Cdks, when activated, the anaphase-promoting complex phosphorylates its targets.
The level of M-cyclin is constant throughout the cell cycle.

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Changes in the activity of a variety of Cdks are essential for accurate progression through the cell cycle, and yet the levels of Cdk expression are fairly constant during the cell cycle. Briefly describe three mechanisms by which the activity of Cdks is regulated.
Which of the following would result in cell cycle arrest? O phosphorylation of Rb by G1-Cdk phosphorylation of p53 O phosphorylation of helicase by S-Cdk phosphorylation of M-Cdk by CAK phosphorylation of APC by M-Cdk
The destruction of the various cyclins is commonly used to inactivate the Cdk/cyclin complexes. Why is it advantageous to inactivate these complexes via protein destruction instead of some other method that does not require the re-synthesis of a cyclin protein the next time the cell divides?
(Q) During M-phase of cell cycle, active M-Cdk phosphorylates several target proteins in order to regulate their activities. Identify TWO specific examples of such target proteins that are phosphorylated by active M-Cdk, and explain how each of them affects the cell (i.e. their respective biological significance). i) target protein phosphorylated: _______________________________ Biological Significance: ii) target protein phosphorylated: _______________________________ Biological Significance:
Notch signaling orchestrates transition from G1 to S phase of cell cycle by multiple other interactions that target the G1/S checkpoint machinery. This is a highly conserved pathway that is seen across multiple kingdoms of life and the ligands involved in notch signaling are typically membrane-bound proteins. This suggests that: -This pathway relies on hormone interactions via endocrine pathways -This pathway relies on signal propagation via paracrine molecules -This pathway relies on direct signaling across gap junctions -This pathway relies on cell binding via autocrine signaling
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What from mitosis is triggered by mitotic CDK inactivationmainly brought about by mitotic cyclin degradation.
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In cell cycle, under the control system, explain in details (including roles of related proteins): During M phase, how M-Cdk can trigger cohesin dissociation as well as Mad2 triggers mitotic checkpoint to delay metaphase to anaphase transition.
The following figure shows how the activities (y-axis) of Cdk-Cyclin B complex and the APC complex change through the cell cycle. Active Cdk1-Cyclin Inactive Cdk1-Cyclin Active APC A B A B time
The cell cycle is typically thought of as having four stages. Describe the stages of the cell cycle and identify the mechanism(s) involved in progressing or not progressing through the stages with reference to proteins and signalling processes involved. Please keep brief - 10 sentences/dot points max.
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