The following graph shows that if a neuron is depolarized briefly and then hyperpolarized slightly, Na+ current can reactivate a "resurgent current. Which of following could explain prolonged and rapid action potential firing despite hyperpolarization? A 30 0- mV -30- -60 -90 -70 mV -60 mV -50 mV 40 mV 100 pA 20 ms -30 mV -20 mV

Human Physiology: From Cells to Systems (MindTap Course List)
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Chapter4: Principles Of Neural And Hormonal Communication
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Problem 1RE: Conformational changes in channel proteins brought about by voltage changes are responsible for...
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The following graph shows that if a neuron is depolarized briefly and then hyperpolarized slightly, Na+ current can reactivate a "resurgent current. Which of the
following could explain prolonged and rapid action potential firing despite hyperpolarization?
A
30
mV -30-
-60-
-90
-70 mV
-60 mV
-50 mV
-40 mV
100 pA
20 ms
30 mV
-20 mV
7:00
Transcribed Image Text:The following graph shows that if a neuron is depolarized briefly and then hyperpolarized slightly, Na+ current can reactivate a "resurgent current. Which of the following could explain prolonged and rapid action potential firing despite hyperpolarization? A 30 mV -30- -60- -90 -70 mV -60 mV -50 mV -40 mV 100 pA 20 ms 30 mV -20 mV 7:00
-40 mV
100 pA
20 ms
-30 mV
-20 mV
-30 mV
T=21 ms
Closure of inactivation gate
Closure of activation gate
Removal of NaVB4 from the pore upon hyperpolarization
Removal of NaVB4 from the pore upon depolarization
Transcribed Image Text:-40 mV 100 pA 20 ms -30 mV -20 mV -30 mV T=21 ms Closure of inactivation gate Closure of activation gate Removal of NaVB4 from the pore upon hyperpolarization Removal of NaVB4 from the pore upon depolarization
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