Signaling activity of G proteins is controlled by GTPase activating proteins (GAPs) and Guanine exchange factors (GEFs). What are the mechanisms by which GAPS and GEFs control G protein functions? GEFS inhibit G protein functions by stimulating GTP hydrolysis; GAPs activate G protein functions by stimulating GDP-GTP exchange. GAPS inhibit G protein functions by stimulating GTP hydrolysis; GEFs activate G protein functions by stimulating GDP-GTP exchange. GEFS inhibit G protein functions by stimulating GTP hydrolysis; GAPS activate G protein functions by inhibiting GDP-GTP exchange. GAPs stimulate G protein functions by blocking GTP hydrolysis; GEFs inhibit G protein functions by stimulating GTP-GDP exchange. GAPS inhibit G protein functions by stimulating GDP-GTP exchange; GEFS activate G protein functions by stimulating GTR budu

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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**Title: Mechanisms of G Protein Regulation by GAPs and GEFs**

**Content:**

The signaling activity of G proteins is controlled by GTPase activating proteins (GAPs) and Guanine exchange factors (GEFs). Understanding the mechanisms by which these proteins control G protein functions is essential in cellular biology. Below are options describing how GAPs and GEFs influence G proteins:

- **Option 1:**  
  GEFs inhibit G protein functions by stimulating GTP hydrolysis; GAPs activate G protein functions by stimulating GDP-GTP exchange.

- **Option 2:**  
  GAPs inhibit G protein functions by stimulating GTP hydrolysis; GEFs activate G protein functions by stimulating GDP-GTP exchange.

- **Option 3:**  
  GEFs inhibit G protein functions by stimulating GTP hydrolysis; GAPs activate G protein functions by inhibiting GDP-GTP exchange.

- **Option 4:**  
  GAPs stimulate G protein functions by blocking GTP hydrolysis; GEFs inhibit G protein functions by stimulating GTP-GDP exchange.

- **Option 5:**  
  GAPs inhibit G protein functions by stimulating GDP-GTP exchange; GEFs activate G protein functions by stimulating GTP hydrolysis.

**Analysis:**  
This content outlines the theoretical roles of GAPs and GEFs in regulating G protein activities through various mechanisms involving GTP and GDP exchanges and hydrolysis. Understanding these options aids in comprehending cell signaling pathways.
Transcribed Image Text:**Title: Mechanisms of G Protein Regulation by GAPs and GEFs** **Content:** The signaling activity of G proteins is controlled by GTPase activating proteins (GAPs) and Guanine exchange factors (GEFs). Understanding the mechanisms by which these proteins control G protein functions is essential in cellular biology. Below are options describing how GAPs and GEFs influence G proteins: - **Option 1:** GEFs inhibit G protein functions by stimulating GTP hydrolysis; GAPs activate G protein functions by stimulating GDP-GTP exchange. - **Option 2:** GAPs inhibit G protein functions by stimulating GTP hydrolysis; GEFs activate G protein functions by stimulating GDP-GTP exchange. - **Option 3:** GEFs inhibit G protein functions by stimulating GTP hydrolysis; GAPs activate G protein functions by inhibiting GDP-GTP exchange. - **Option 4:** GAPs stimulate G protein functions by blocking GTP hydrolysis; GEFs inhibit G protein functions by stimulating GTP-GDP exchange. - **Option 5:** GAPs inhibit G protein functions by stimulating GDP-GTP exchange; GEFs activate G protein functions by stimulating GTP hydrolysis. **Analysis:** This content outlines the theoretical roles of GAPs and GEFs in regulating G protein activities through various mechanisms involving GTP and GDP exchanges and hydrolysis. Understanding these options aids in comprehending cell signaling pathways.
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