QUESTION 1 The Wnt signaling pathway component, Dsh, effects the action of B catenin by: O A. inhibiting the function of axin in the destruction complex O B. blocking GSK-3B from joining the destruction complex O C. stimulating ubiquitination of ß catenin O D. causing its release into the cytosol from the plasma membrane complex O E. causing an increase in phophorylation of B catenin QUESTION 2 PCR can be used to identify the breakage points of mtDNA that are joined to form a mitochondrial genome with a deletion. This techni que uses: O A. two primers outside the deleted region; a long PCR extension segment. O B. one primer within the deleted region and one primer outside the deleted region; a long PCR extension segment O C. one primer within the deleted region and one primer outside the deleted region; a short PCR extension segment O D. two primers outside the deleted region; a short PCR extension segment O E. two primers within the deleted region; a short PCR extension segment

Question 5

QUESTION 34 Which of the following events does NOT occur during ERAD (ER-associated degradation)? OA. Chaperone-mediated attempts at protein folding OB. Degradation of misfolded proteins by the proteasome OC. Targeting of mis-folded proteins to the nucleus OD. Repeated attempts at protein folding QUESTION 35 Which of the following statements regarding COPII vesicles trafficking between the ER and the Golgi is NOT correct? OA. Uncoated vesicles fuse with the cis-Golgi. OB. The vesicle enclosed in a COPII coat fuses with the cis-Golgi. OC. The COPII vesicles lose the COPII coat before reaching the Golgi. OD. COPII-coated vesicles bud off from the RER. QUESTION 36 Which phenotype would you expect to see in cells that contain a defective Rab GTPase that cannot be activated on the inner surface plasma membrane? OA. The cell would lack secretory vesicles. OB. No phenotype OC. The cell would have an excess of secretory vesicles within the cytoplasm and defective secretion. OD. The cell would…

QUESTION 1 The Wnt signaling pathway component, Dsh, effects the action of B catenin by: O A. inhibiting the function of axin in the destruction complex O B. blocking GSK-3B from joining the destruction complex O C. stimulating ubiquitination of B catenin O D. causing its release into the cytosol from the plasSma membrane complex O E. causing an increase in phophorylation of B catenin QUESTION 2 PCR can be used to identify the breakage points of mtDNA that are joined to form a mitochondrial genome with a deletion. This technique uses: O A. two primers outside the deleted region; a long PCR extension segment. O B. one primer within the deleted region and one primer outside the deleted region; a long PCR extension segment O C. one primer within the deleted region and one primer outside the deleted region; a short PCR extension segment O D. two primers outside the deleted region; a short PCR extension segment O E. two primers within the deleted region; a short PCR extension segment