Biochemistry
9th Edition
ISBN: 9781319114671
Author: Lubert Stryer, Jeremy M. Berg, John L. Tymoczko, Gregory J. Gatto Jr.
Publisher: W. H. Freeman
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- What activates CREB? OBinding of CAMP O Phosphorylation O Dimerization O ASUKKERI Masau None of the answers are correctarrow_forwardHelp filling in the blanks: Pyridoxal phosphate, PLP, is produced from pyridoxine or vitamin B6. PLP is considered a/an [1C/2C/acyl/amino/carboxyl] carrier. In transaminases, PLP forms a [Schiff base/acetal/phosphoanhydride/condensation] with an amino acid and causes the [a- amino/a-carbon/a-carboxyl] to become [electrophilic/nucleophilic] allowing replacement of the amino group on the amino acid with a ketone. PLP is also used by several other enzymes that work on amino acids because in forming a covalent bond with amino acids it provides for an opportunity for nucleophilic attack and because PLP is conjugated, the cofactor is able to [delocalize/transfer/reduce/stabilize] pi electrons in the substrate and thus [stabilize/delocalize/transfer/reduce] the transition state of the reaction. Production of citrulline occurs in the [cytosol/mitochondrial matrix] while the rest of the urea cycle occurs in the [cytosol/mitochondrial matrix]. Urea is produced in the…arrow_forwardEnzyme activity is dependent on many factors. List at least three different factors that could negatively impact enzyme activity and describe one use for each instance in the body. (IE. Oxycontin binds to enzyme active sites responsible for transferring pain signals, thus would be considered aarrow_forward
- A defect in which of the following enzymes leads to Tay- Sachs disease? O Phospholipase CO a-galactosidase A O Hexosamidase A O Sphingomyelinasearrow_forwardIn the first cycle of fatty acid synthesis via the acyl carrier protein system, the acetyl group on fatty acid synthase condenses with the malonyl-ACP complex. Draw the structure of the products of this reaction. Respresent ACP by R1 do not include free synthase Be sure to include charges on atoms at Ph=7arrow_forwardselect the BEST answer Aconitase is most interesting in that it: Can be coded for by 2 different genes O Exists as either a membrane bound or soluble protein depending on intracellular conditions O Has 2 distinct roles depending on the availability of Iron O Can change the AGº' of it's reaction O Is itself an allosteric regulator of the PDH complexarrow_forward
- n your own words and with your own diagrams, describe the catalytic reaction mechanism of the enzyme acetylcholinesterase. Discuss the functional roles of each member of the catalytic triad plus whatever other residues that you find important. Describe the actual movements of protons, and the making and breaking of bonds. What types of chemistries is the enzyme using? (what is the enzyme doing, in term of reactionarrow_forwardAll of the following compounds have sufficiently high group transfer potentials to lead to the production of ATP except: 1,3-bisphosphoglycerate. acetyl-CoA. O phosphocreatine. glucose-6-phosphate. phosphoenolpyruvate.arrow_forwardWhich of the following statements is WRONG with regard to the following molecule? HO O OH NH₂ N It is made from ATP It activates PKA It is highly unstable and rapidly breaks down on its own. It is involved in adrenaline signaling.arrow_forward
- Folate deficiency in a cancer patient being treated with 5-Fluorouracil will lead to diminished capacity of this drug to inhibit thymidylate synthase. Group of answer choices True Falsearrow_forwardPlz do itarrow_forwardWhich of the following mechanisms of reversible enzyme inhibition describe the mode of action of nevirapine? Non-competitive Competitive Über-competitive Mixed Uncompetitivearrow_forward
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