out transformation requires from 105 to 124 genes, collectively termed the com regulon. The com regulon is activated in response to a protein called competence-stimulating peptide (CSP), which is produced by the bacteria and exported into the surrounding medium. When enough CSP accumulates, it attaches to a receptor on the bacterial cell membrane. The receptor then activates a regulator protein that stimulates the transcription of genes within the com regulon and sets in motion a signaling cascade that results in transformation. Does the com regulon in S. pneumoniae exhibit positive or negative control? Explain your answer. negative control, wherein CSP is a repressor of the com pathway, which stimulates transcription negative control, wherein CSP activates the membrane receptor, which turns on transcription of various genes O positive control, wherein CSP binds to membrane receptors and stimulates the regulon, which suppresses transcription at multiple loci cannot be determined because no information is provided about the structural genes involved O positive control, wherein CSP activates the membrane receptor and turns on transcription at com regulon genes

Human Anatomy & Physiology (11th Edition)
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Chapter1: The Human Body: An Orientation
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Transformation is a process in which bacteria take up new DNA released by dead cells and integrate it into their own genomes.
In Streptococcus pneumoniae (which causes many cases of pneumonia, inner ear infections, and meningitis), the ability to carry
out transformation requires from 105 to 124 genes, collectively termed the com regulon. The com regulon is activated in
response to a protein called competence-stimulating peptide (CSP), which is produced by the bacteria and exported into the
surrounding medium.
When enough CSP accumulates, it attaches to a receptor on the bacterial cell membrane. The receptor then activates a regulator
protein that stimulates the transcription of genes within the com regulon and sets in motion a signaling cascade that results
in transformation.
Does the com regulon in S. pneumoniae exhibit positive or negative control? Explain your answer.
negative control, wherein CSP is a repressor of the com pathway, which stimulates transcription
negative control, wherein CSP activates the membrane receptor, which turns on transcription of various genes
O positive control, wherein CSP binds to membrane receptors and stimulates the regulon, which suppresses transcription
at multiple loci
cannot be determined because no information is provided about the structural genes involved
O positive control, wherein CSP activates the membrane receptor and turns on transcription at com regulon genes
Transcribed Image Text:Transformation is a process in which bacteria take up new DNA released by dead cells and integrate it into their own genomes. In Streptococcus pneumoniae (which causes many cases of pneumonia, inner ear infections, and meningitis), the ability to carry out transformation requires from 105 to 124 genes, collectively termed the com regulon. The com regulon is activated in response to a protein called competence-stimulating peptide (CSP), which is produced by the bacteria and exported into the surrounding medium. When enough CSP accumulates, it attaches to a receptor on the bacterial cell membrane. The receptor then activates a regulator protein that stimulates the transcription of genes within the com regulon and sets in motion a signaling cascade that results in transformation. Does the com regulon in S. pneumoniae exhibit positive or negative control? Explain your answer. negative control, wherein CSP is a repressor of the com pathway, which stimulates transcription negative control, wherein CSP activates the membrane receptor, which turns on transcription of various genes O positive control, wherein CSP binds to membrane receptors and stimulates the regulon, which suppresses transcription at multiple loci cannot be determined because no information is provided about the structural genes involved O positive control, wherein CSP activates the membrane receptor and turns on transcription at com regulon genes
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