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8. Consider a relaxed, covalently-closed circular DNA plasmid that has 2080 base pairs with Wr = 0. An intercalator molecule is added, such that there is one intercalator per104 base pairs. The effect of the intercalator is to cause the twist between the base pairs that flank it to be reduced to zero. What will be the resulting change in supercoiling state (i.e., the Linking Number) for the intercalator-bound DNA ?

8. Consider a relaxed, covalently-closed circular DNA plasmid that has 2080 base pairs with Wr = 0. An intercalator molecule is added, such that there is one intercalator per104 base pairs. The effect of the intercalator is to cause the twist between the base pairs that flank it to be reduced to zero. What will be the resulting change in supercoiling state (i.e., the Linking Number) for the intercalator-bound DNA ?

Human Anatomy & Physiology (11th Edition)
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
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8. Consider a relaxed, covalently-closed circular DNA plasmid that has 2080 base pairs with Wr = 0. An intercalator molecule is added, such that there is one intercalator per 104 base pairs. The effect of the intercalator is to cause the twist between the base pairs that flank it to be reduced to zero. What will be the resulting change in supercoiling state (i.e., the Linking Number) for the intercalator-bound DNA ?
Transcribed Image Text:8. Consider a relaxed, covalently-closed circular DNA plasmid that has 2080 base pairs with Wr = 0. An intercalator molecule is added, such that there is one intercalator per 104 base pairs. The effect of the intercalator is to cause the twist between the base pairs that flank it to be reduced to zero. What will be the resulting change in supercoiling state (i.e., the Linking Number) for the intercalator-bound DNA ?
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