LO 53- Determine the type of mutations based on the effect in the amino acid chain "missense, nonsense, silent and neutral" - that occurred in a sequence. A mutation in a DNA sequence leads to a shorter protein when compared to the wild-type protein. This means:

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter3: The Cellular Level Of Organization
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LO 53- Determine the type of mutations based on the effect in the amino acid chain "missense, nonsense,
silent and neutral"- that occurred in a sequence.
A mutation in a DNA sequence leads to a shorter protein when compared to the wild-type protein. This
means:
The mutation is missense because the protein is shorter
The mutation is neutral because it leads to a stop codon earlier than the wild-type sequence
The mutation is nonsense because it leads to a stop codon earlier than the wild-type sequence.
The change represents a gain of function mutation
The mutation is nonsense because it leads to a stop codon at a later codon than the wild-type sequence
Transcribed Image Text:LO 53- Determine the type of mutations based on the effect in the amino acid chain "missense, nonsense, silent and neutral"- that occurred in a sequence. A mutation in a DNA sequence leads to a shorter protein when compared to the wild-type protein. This means: The mutation is missense because the protein is shorter The mutation is neutral because it leads to a stop codon earlier than the wild-type sequence The mutation is nonsense because it leads to a stop codon earlier than the wild-type sequence. The change represents a gain of function mutation The mutation is nonsense because it leads to a stop codon at a later codon than the wild-type sequence
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