Intro to Neuro Question: Huntington’s disease causes too much ballistic movement due to which of the following reasons? Group of answer choices Loss of the inhibitory connection between the striatum and the globus pallidus external Loss of the inhibitory connection between the striatum and the globus pallidus internal Loss of the inhibitory connection between the globus pallidus external and the globus pallidus internal Increased activity of

Anatomy & Physiology
1st Edition
ISBN:9781938168130
Author:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Publisher:Kelly A. Young, James A. Wise, Peter DeSaix, Dean H. Kruse, Brandon Poe, Eddie Johnson, Jody E. Johnson, Oksana Korol, J. Gordon Betts, Mark Womble
Chapter14: The Somatic Nervous System
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Intro to Neuro Question: Huntington’s disease causes too much ballistic movement due to which of the following reasons?

Group of answer choices
Loss of the inhibitory connection between the striatum and the globus pallidus external
Loss of the inhibitory connection between the striatum and the globus pallidus internal
Loss of the inhibitory connection between the globus pallidus external and the globus pallidus internal
Increased activity of globus pallidus internal neurons
 
Is my reasoning correct?

Huntington's disease is characterized by the degeneration of neurons in the striatum, particularly those that project to the globus pallidus external (GPe) in the indirect pathway.

The correct reason for too much ballistic movement in Huntington's disease is:

Loss of the inhibitory connection between the striatum and the globus pallidus external.

This loss weakens the indirect pathway, reducing its ability to suppress unwanted movements, leading to the hyperkinetic symptoms like chorea seen in Huntington's disease.

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