Intro to Neuro Question Dopamine input from the substantia nigra to the striatum results in which of the following? increased firing of thalamus neurons decreased firing of thalamus neurons increased firing of globus pallidus internal neurons decreased firing of globus pallidus internal neurons increased firing of globus pallidus external neurons decreased firing of globus pallidus external neurons Group of answer choices I, III and V I, IV and V II, III and V I, IV, and VI Is my reasoning correct? Dopamine from the substantia nigra: Excites the direct pathway in the striatum, leading to decreased activity in the globus pallidus internal (GPi) and increased activity in the thalamus. Inhibits the indirect pathway in the striatum, resulting in decreased activity in the globus pallidus external (GPe) and further decreasing GPi activity, which also increases thalamic activity. So, the effects are: Increased firing of thalamus neurons. Decreased firing of globus pallidus internal neurons. Decreased firing of globus pallidus external neurons. Answer: I, IV, and VI.

Human Anatomy & Physiology (11th Edition)
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Intro to Neuro Question

Dopamine input from the substantia nigra to the striatum results in which of the following? increased firing of thalamus neurons decreased firing of thalamus neurons increased firing of globus pallidus internal neurons decreased firing of globus pallidus internal neurons increased firing of globus pallidus external neurons decreased firing of globus pallidus external neurons
Group of answer choices
I, III and V
I, IV and V
II, III and V
I, IV, and VI

Is my reasoning correct? Dopamine from the substantia nigra:

  1. Excites the direct pathway in the striatum, leading to decreased activity in the globus pallidus internal (GPi) and increased activity in the thalamus.
  2. Inhibits the indirect pathway in the striatum, resulting in decreased activity in the globus pallidus external (GPe) and further decreasing GPi activity, which also increases thalamic activity.

So, the effects are:

  • Increased firing of thalamus neurons.
  • Decreased firing of globus pallidus internal neurons.
  • Decreased firing of globus pallidus external neurons.

Answer: I, IV, and VI.

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