Read the scenario presented in the picture.The conditions employed in laboratory settings could mimic the outcomes of prolonged usage of tamoxifen and hormone deprivation therapy. We don't know much about the phenotypic profile of these newly emerged cancer cells. How might you explain the lack of response of TamC3 to tamoxifen treatment and TamR3 to estrogen deprivation? Part III - Generating TamC3 and TamR3 Cell LinesAs Emily, Eric, and Lena entered the conference room, they found Dr. Mendoza helping himself to coffee and adoughnut, seated at a conference table with a couple of graduate students."Dr. Mendoza, I would like you to meet Emily, our internship student from Alfred, New York. Dr. Mendoza is anoncologist, and he works at the clinic. We collaborate," said Eric."Hi Emily! Nice to meet you. Would you like a cup of coffee?""Hello Dr. Mendoza, yes. Thank you.""You've already met the rest of the group. I gather they took you out last night. Did you guys have fun?" Eric smiled ashe looked at Mike and Jen, the graduate students in his lab."Yes boss! We need more time off like this," replied Mike."OK, who is presenting first today?" asked Eric."I'm up," said Mike coming up to the white screen, where the PowerPoint presentation with the experimental resultswould be displayed. Lena dimmed the lights and Mike started his presentation."Some breast cancer cells can develop resistance to the tamoxifen treatment and can survive the estrogen deprivationconditions. The mechanisms of the drug and hormone deprivation resistance are not known. To investigate thisphenomenon, we took the MCF-7 cells into the laboratory""Did I you try to make the cell resistant to tamoxifen?" asked Dr. Mendoza."Yes. We divided them into two groups. One batch of the cells was exposed to tamoxifen for some period of time,which we did to mimic the clinical condition for the tamoxifen treatment in patients. Some of the cells died duringthe course of the experiment, but those that survived were selected and cultivated further.""Wow!" interrupted Eric. "So in this way you generated a new cell line. What did you call it?""We're calling it TamC3. These cells were resistant to tamoxifen.The other batch of the MCF-7 cells was subjected to conditionswithout estrogen.""Very clever!" this time Dr. Mendoza interrupted. "That's mimick-ing the condition in patients subjected to hormone deprivationtherapy. And what happened?""The cells that survived the estrogen deprivation established anothercell line, TamR3. Those cells are estrogen independent. Look atthis graph," replied Mike (Figure 1).TamC3TamoxifenMCF-7Estrogen deprivationTamR3Figure 1. Generation of tamoxifen resistant (TamC3)and estrogen-independent (TamR3) cell lines.

Question

Read the scenario presented in the picture.The conditions employed in laboratory settings could mimic the outcomes of prolonged usage of tamoxifen and hormone deprivation therapy. We don't know much about the phenotypic profile of these newly emerged cancer cells. How might you explain the lack of response of TamC3 to tamoxifen treatment and TamR3 to estrogen deprivation? Part III - Generating TamC3 and TamR3 Cell LinesAs Emily, Eric, and Lena entered the conference room, they found Dr. Mendoza helping himself to coffee and adoughnut, seated at a conference table with a couple of graduate students.&#34;Dr. Mendoza, I would like you to meet Emily, our internship student from Alfred, New York. Dr. Mendoza is anoncologist, and he works at the clinic. We collaborate,&#34; said Eric.&#34;Hi Emily! Nice to meet you. Would you like a cup of coffee?&#34;&#34;Hello Dr. Mendoza, yes. Thank you.&#34;&#34;You've already met the rest of the group. I gather they took you out last night. Did you guys have fun?&#34; Eric smiled ashe looked at Mike and Jen, the graduate students in his lab.&#34;Yes boss! We need more time off like this,&#34; replied Mike.&#34;OK, who is presenting first today?&#34; asked Eric.&#34;I'm up,&#34; said Mike coming up to the white screen, where the PowerPoint presentation with the experimental resultswould be displayed. Lena dimmed the lights and Mike started his presentation.&#34;Some breast cancer cells can develop resistance to the tamoxifen treatment and can survive the estrogen deprivationconditions. The mechanisms of the drug and hormone deprivation resistance are not known. To investigate thisphenomenon, we took the MCF-7 cells into the laboratory&#34;&#34;Did I you try to make the cell resistant to tamoxifen?&#34; asked Dr. Mendoza.&#34;Yes. We divided them into two groups. One batch of the cells was exposed to tamoxifen for some period of time,which we did to mimic the clinical condition for the tamoxifen treatment in patients. Some of the cells died duringthe course of the experiment, but those that survived were selected and cultivated further.&#34;&#34;Wow!&#34; interrupted Eric. &#34;So in this way you generated a new cell line. What did you call it?&#34;&#34;We're calling it TamC3. These cells were resistant to tamoxifen.The other batch of the MCF-7 cells was subjected to conditionswithout estrogen.&#34;&#34;Very clever!&#34; this time Dr. Mendoza interrupted. &#34;That's mimick-ing the condition in patients subjected to hormone deprivationtherapy. And what happened?&#34;&#34;The cells that survived the estrogen deprivation established anothercell line, TamR3. Those cells are estrogen independent. Look atthis graph,&#34; replied Mike (Figure 1).TamC3TamoxifenMCF-7Estrogen deprivationTamR3Figure 1. Generation of tamoxifen resistant (TamC3)and estrogen-independent (TamR3) cell lines.

Accepted Answer

To effectively analyze and address the question presented in the passage, which discusses the lack…