alpha-amanitin is an extremely deadly toxin produced by death cap mushrooms. It specifically blocks the activity of RNA polymerase II, but not other RNA polymerases. Based on what we've learned in class so far, what's the most likely molecular mechanism leading to fatality when a human eats a death cap mushroom? Group of answer choices Failure to transcribe rRNA Failure of sigma factor to bind to promoter Failure to replicate DNA Failure to transcribe pre-mRNA Failure to transcribe tRNA Failure to translate polypeptides

alpha-amanitin is an extremely deadly toxin produced by death cap mushrooms. It specifically blocks the activity of RNA polymerase II, but not other RNA polymerases. Based on what we've learned in class so far, what's the most likely molecular mechanism leading to fatality when a human eats a death cap mushroom? Group of answer choices Failure to transcribe rRNA Failure of sigma factor to bind to promoter Failure to replicate DNA Failure to transcribe pre-mRNA Failure to transcribe tRNA Failure to translate polypeptides

Biochemistry

6th Edition

ISBN:9781305577206

Author:Reginald H. Garrett, Charles M. Grisham

Publisher:Reginald H. Garrett, Charles M. Grisham

Chapter29: Transcription And The Regulation Of Gene Expression

Section: Chapter Questions

Problem 17P

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Figure 2 below is a schematic diagram illustrating a short gene with 5000 bp of an unknown Escherichia coli genome. (Note: Transcription Start Site (TSS)) (1) (ii) TSS +1 3 5² Figure 2 Draw and name the specific regions in Figure 2 that can be recognized by Sigma Factor and explain the function of Sigma Factor. Which strand of DNA shown (top or bottom) is the coding strand?
Give the RNA molecule sequence transcribed from the following DNA sequence of a eukaryotic gene and with the correct 5' and 3' ends. DNA: 5'-ATAGGGCATGT-3' 3'-TATCCCGTACA-5' <--- template strand Group of answer choices 5'-ATAGGGCATGT-3' 3'-UAUCCCGUACA-5' 5'-AUAGGGCAUGU-3' 3'-TATCCCGTACA-5'
In what ways does the double helix explain the essential properties of a gene? What are Chargaff’s rules? Phage T2 is estimated to consist of about 200,000 deoxyribonucleotides pairs. Give the length in micrometer of its DNA complement.
In relation to central dogma of molecular biology answer the following questions: The following segment of DNA is part of the transcription unit of a gene. You know already that RNA polymerase moves in a specific direction along this piece of DNA to convert one of the DNA strands into a single strand RNA transcript so that this entire region of DNA is made into RNA. 5′-GGCATGGCAATATTGTAGTA-3′ 3′-CCGTACCGTTATAACATCAT-5′ Given this information, a student claims that the RNA produced from this DNA is: 3′-GGCATGGCAATATTGTAGTA-5′ Give two reasons why this answer is incorrect.
A particular variant of the lambda bacteriophage has a DNA double-stranded genome of 51,365 base pairs. How long would this DNA be?
The beginning of the hexose kinase gene's sequence can be found below, the +1 nucleotide is underlined and bolded. It also contains an origin of replication (ORI) which is found at position 30. 1 20 ORI 40 60 5'.TTCGAGCTCTCGTCGTCGAGATACGCGATGATATTACTGGTAATATGGGGATGCACTATC...3' 3'.AAGCTCGAGAGCAGCAGCTCTATGCGCTACTATAATGACCATTATACCCCTACGTGATAG...5' promoter 2a. Assume that replication has been initiated at that ORI. Provide the sequence of the primer that is complementary to the DNA in each of the following positions. d Site A - binding to the top strand of the DNA at position 20 – 30 5' 3' Site B - binding to the top strand of the DNA at position 31 -41 5' 3' 2b. Replication is occurring normally in these cells; would you expect to find a primer in both positions? Why or why not?
The schematic dlagram below shows the functional organization of transcribing RNA polymerase. Match parts of the diagram (labeled A-G) with the corresponding term from the answer list (design ated 1-12). Polymerase movement ANA POLYMERASE A Rowinding of DNA Unwinding of DNA E NTPs Note that some of the items from the answer list should NOT be used. Labels E and F point to the specific ends of DNA/RNA molecules. 1. Template strand 2. RNA transcript 3. Replication origin 4 Non-Template strand 5. Leading strand 6. 3 end 7. Primer 8. Replication fork 9. Transcription bubble 10. 5' end 11. DNA RNA nybrid 12. Lagging strand
The beginning of the hexose kinase gene's sequence can be found below, the +1 nucleotide is underlined and bolded. It also contains an origin of replication (ORI) which is found at position 30. 20 ORI 40 60 5'..TTCGAGCTCTCGTCGTCGAGATACGCGATGATATTACTGGTAATATGGGGATGCACTATC...3' 3'...AAGCTCGAGAGCAGCAGCTСТАТGCGCTАСТАТААTGACСАТТАТАССССТАСGTGATAG...5" promoter a. Assume that replication has been initiated at that ORI. Provide the sequence of the primer that is complementary to the DNA in each of the following positions. Site A - binding to the top strand of the DNA at position 20 – 30 5' 3' Site B - binding to the top strand of the DNA at position 31 – 41 5' 3'
THE MOLECULAR GENETICS OF CYSTIC FIBROSIS and of The following is the base sequence of DNA that codes for amino acids 506-510 of the protein that regulates the chlorine channels in the cell membrane. This protein contains a total of 1476 amino acids so this is a small part of the entire gene. DNA Template Strand: 3'TAGTAGAAACCACAA5' 1. What is the minimum number of DNA nucleotides in this whole gene? 2. What is the sequence of bases on the strand of DNA that is complementary to the template strand? 3. What mRNA will be formed from the template strand of DNA? 4. What amino acids will this mRNA code for? 5. If the 6th, 7th and 8th bases in the template strand of the DNA are removed, rewrite the new template strand below. 6. When the template strand of the DNA is changed, this is referred to as a mutation. What kind of mutation is this? 65
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The sequence below is of the DNA duplex for a gene in which transcription begins with the nucleotide highlighted by the arrow. If the upper strand shown is the template strand, write the sequence you expect for the mRNA transcribed from this gene. Please write 5' to 3'. 5'-[x]-3' 5'-TACGTGACGGTAATACTAGC-3' 3'-ATGCACTGCCATTATGATCG-5'
A certain section of the coding (sense) strand of some DNA looks like this: 5'- ATGGGCCACTCATCTTAG-3' It's known that a very small gene is contained in this section. Classify each of the possible mutations of this DNA shown in the table below. I Don't Know mutant DNA 5'- ATG GGCCACAGTTCTTAG-3' 5'- ATG GG CTCATCTTAG - 3' 5'- ATG GGCCACGCATCTTAG-3' Submit type of mutation (check all that apply) ооооо O point O silent O noisy ооооо insertion deletion insertion O deletion Opoint Osilent noisy insertion O deletion ооооо Opoint silent O noisy X S Ⓒ2023 McGraw Hill LLC. All Rights Reserved. Terms of Use | Privacy Center Accessibility