A 24 year old previously healthy woman is evaluated for skin rash, joint pains, and renal failure. Sheis found to have decreased C3 and C4 levels and a normal factor B level. Which of the following most likely triggered the complement systemactivation in this patient? (A) Antigens binding to igA (B) Autoactivation of C3 component (C) C1 components binding to C1 inhibitor (D) C9- Lipid membrane complex formation (E)IgG antigen complex formation

A 24 year old previously healthy woman is evaluated for skin rash, joint pains, and renal failure. Sheis found to have decreased C3 and C4 levels and a normal factor B level. Which of the following most likely triggered the complement systemactivation in this patient? (A) Antigens binding to igA (B) Autoactivation of C3 component (C) C1 components binding to C1 inhibitor (D) C9- Lipid membrane complex formation (E)IgG antigen complex formation

Concepts of Biology

1st Edition

ISBN:9781938168116

Author:Samantha Fowler, Rebecca Roush, James Wise

Publisher:Samantha Fowler, Rebecca Roush, James Wise

Chapter17: The Immune System And Disease

Section: Chapter Questions

Problem 19CTQ: If a series of genetic mutations prevented some, but not all, of the complement proteins from...

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Which of the following is not true about the complementsystem?(a) It is a set of more than 20 proteins that play a key rolein host defense by specifically acting in different waystoward different microorganisms.(b) Its general functions include enhancing phagocytosis byphagocytes, lysing microbes and enveloped viruses directly, and generating peptide fragments that regulateinflammation and immune responses.(c) It is a fast-acting innate host defense that works in a cascade.(d) There are three pathways classical, lectin, and alternative.(e) The effects of each activation pathways are the same.
State whether each of the following statements is True Or False. If it is False, explain why. (i) Nucleated cells tend to be more resistant to complement-mediated lysis than red blood cells. (ii) The C4 and C2 complement components are present in the serum in a functionally inactive proenzyme from.
Which of the following types of antibodies may function to trigger the nonspecific event of complement activation? Choose from the following: (A) IgG and IgA (B) IgD and IgM (C) IgD and IgE (D) IgG and IgM (E) IgA and IgE
Complement receptors and Fc receptors both contribute to removal of immune complexes from the circulation. Surprisingly, individuals with defects in the early components of the classical complement cascade (i.e., C1, C2, or C4) suffer from an autoimmune type of kidney damage, rather than from an immunodeficiency leading to increased susceptibility to infections. Why do these complement defects lead to autoimmune kidney damage?
Splitting the complement protein (C3) into C3a and C3b as a result of contact with the Fc region of antibodies coating a bacterium illustrates the onset of which of the following ? Choose from the following: (A) classical pathway of complement activation (B) alternate pathway of complement activation
(47) A 40 year old man with a compliment deficiency agrees to participate in a clinical study of immune mechanism.The subject is unable to activate the complement system by classical pathway, but he can activate the complement system by alternate pathway.Deletion of which of the following compliments is consistent with these findings? (A) C2 (B) C3 (C) C5 (D) C8 (E) Factor B (F) Factor D (G) Factor H (H) von Willebrand factor
1) Which other complement complex has homologous structure to C1qr2s2? a) MBL complexed with MASP1/2 (c) C5a6789 b) Pentameric igm (d) C3bBb 2) Which of the following types of receptors doesn't directly contribute phagocytosis? a) FcR (B) TLR (C) TCR (D) CR1
.A table comparing the biological characteristics of the five classes of immunoglobulins is shown below. Answer yes or no in the spaces provided, (You can draw the table in your answer paper) IgE IgD Biological activity a) Activates classical complement pathway b) Present on the membrane of the mature B cells c) Present in secretions d) Induces mast-cell degranulation e) Crosses placenta IgG IgA IgM
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Immune system of humans a) Secreted B cell receptors can function as opsonins. b) MHC class II molecules can be found on the surface of nearly every cell of the body. c) The membrane attack complex (MAC) is used by natural killer cells to eliminate virus infected host cells. d) Both (a) and (b) are correct and (c) is incorrect e) Statements (a), (b) and (c) are all correct
For each of the following situations, indicate which type(s) of lymphocyte(s), if any, would be expected to proliferate rapidly in lymph nodes and where in the nodes they would do so. Nomal mouse with a viral infection (a) (b) (c) Neonatally thymectomized mouse immunized with a protein antigen Neonatally thymectomized mouse immunized with the thymus-independent antigen bacterial lipopolysaccharide (LPS), which does not require the aid of THcells to activate B cells.
b) Figure 14 shows a part of acquired immune response. Pathogen P Antigen fragments MHC Antigen гесeptor. CD4 Helper T cell Activated helper T cell Figure 14 i) Describe the above process. II) Why do O and P have different pathways for antigen processing although the same antigen is identified? iii) What are the effects on P when activated helper T cell releases Q7