Hypophoshatemia is a dominant genetic disorder caused by deficiency of pho[hates in the blood. Assuming the other parent is free of the disorder, males with the disorder will pass it on to all their daughters but not their sons. Females with the disorder will pass it on to approximately half of their children. a.) Is this pattern of inheritance autosomal or sex-linked? Explain b.) Draw a Punnett square to show the inheritance pattern of the disorder in each of the two scenarios

Amelogenesis imperfecta (AI) is a disorder of faulty tooth enamel formation. It is inherited in an autosomal dominant and X-linked dominant pattern. The expression of AI disorder is determined by mutations in the autosomal alleles. One copy of the mutated allele (A) will cause the disorder. The severity of the disorder is determined by mutations in a gene carried on the X chromosome. Normal (or non-severe) abnormality (XN) is dominant over the abnormality (or severe) (Xn) allele. In the absence of the autosomal dominant allele, the abnormality gene on the X chromosome is not expressed. Question:A woman with normal teeth had four children with a man with non-severe form of AI: A boy was born without amelogenesis imperfecta A girl was born without amelogenesis imperfecta  A boy was born with severe amelogenesis imperfecta A boy was born with non severe amelogenesis imperfecta Identify the parental genotypes.  Complete the Punnett square for the parental cross, and identify the…

a) Which of the four modes of inheritance are consistent with the disease shown in this human pedigrees below? (List the compatible mode or modes) Give an answer for a, b and c b) If the parents in pedigree c have 2 other children, what is the probability that they will carry the disease?

One of your patients, a six-year-old girl who suffers from Sickle cell anemia, an inherited blood disorder in which red blood cells are abnormally shaped and fragile, leading to a short supply of red blood cells.  These abnormal cells can also get stuck in small vessels, which prevent blood flow, leading to fatigue, pain and other severe complications. Sickle cell anemia is an autosomal recessive disorder. Neither of your patient's parents has sickle cell anemia. What is the most likely genotype of her parents? (The normal beta-globin allele is abbreviated as B, and the abnormal allele as b.) one is B and one is b   one is BB and one is bb   both are Bb   both are bb   both are BB

For the following diseases with their potential pedigree, mode of inheritance and the responsible gene: (Pedigrees A, B, and C) -> Do Pedigree A Pedigree B, Autosomal dominant, Huntingtin gene Pedigree B, Autosomal dominant, CFTR gene Pedigree B, Autosomal dominant, HexA gene Pedigree B, Autosomal dominant, FGFR3 gene Pedigree A, Autosomal recessive, CFTR gene Pedigree A, Autosomal recessive, Beta-globin gene Pedigree A, Autosomal dominant, FGFR3 gene Pedigree B, X-linked dominant. Factor VIII gene Pedigree A, Autosomal dominant, Beta-globin gene Pedigree A. Autosomal recessive, Huntingtin gene Pedigree C, X-linked recessive, Factor VIII gene Pedigree A, Autosomal recessive, HexA gene

An unaffected woman for a human disorder marries and unaffected man and they have children. This results in 3 affected sons, and one unaffected daughter, which ends up having children later on with an unaffected man and has 2 affected sons. A) Draw a simple pedigree diagram for this family, including a legend. B) What is the likely mode of inheritance of this trait: Please explain C) Provide the genotypes of the original mother and the daughter. Use a capital letter for the dominant allele and lowercase letter for the recessive allele. D) If one of the affected sons from the original marriage marries a 2nd cousin that is a carrier of this trait and has children, what is the probability that they will have 3 affected sons?

A mother is heterozygous for the X-linked gene for colorblindness and also heterozygous for the autosomal inherited sickle cell anemia. She is married to a man who can see color normally and who is heterozygous for sickle cell trait. Using b (colorblind), B (normal color), S (normal hemoglobin), s (sickle cell), answer the following: a. What are the genotypes of the parents? b: What is the probability of having a child who is both color blind and has sickle cell anemia?