Cultured cells were treated with a compound in early Gap 1 (G₁) phase resulting to arrest before entering S phase. It was identified that similar checkpoint acts during G₁ phase to ensure that sufficient growth has occurred before the cells enter S phase. Which of the following was the most plausible mechanism of arrest? (A) Inhibition of Rb activity (B) Overproduction of E2F (C) Inhibition of DNA polymerase (D) Inhibition of G₁ cyclin transcription

Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Cultured cells were treated with a
compound in early Gap 1 (G₁) phase
resulting to arrest before entering
S phase. It was identified that similar
checkpoint acts during G₁ phase to
ensure that sufficient growth has
occurred before the cells enter S phase.
Which of the following was the most
plausible mechanism of arrest?
(A) Inhibition of Rb activity
(B) Overproduction of E2F
(C)
Inhibition of DNA polymerase
(D) Inhibition of G₁ cyclin transcription
Transcribed Image Text:Cultured cells were treated with a compound in early Gap 1 (G₁) phase resulting to arrest before entering S phase. It was identified that similar checkpoint acts during G₁ phase to ensure that sufficient growth has occurred before the cells enter S phase. Which of the following was the most plausible mechanism of arrest? (A) Inhibition of Rb activity (B) Overproduction of E2F (C) Inhibition of DNA polymerase (D) Inhibition of G₁ cyclin transcription
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