Zeb1 encodes a transcription factor that activates expression of genes that help cells migrate (move to different parts of the body) during embryogenesis. Zeb1 is not expressed in most adult tissues, but can undergo a gain of function mutation in some tumors. Which change is likely to result from a gain of function mutation in Zeb1? a) sustaining proliferative signalling O b) activating invasion and metastasis O c) deregulating cellular energetics O d) resisting cell death

Q: drug that has been screened in cancer model through the generation of induced pluripotent stem…

A: induced pluripotent stem cells are the type of stem cells that are produced from the somatic cells…

Q: Mutations in cancer cells:  a.) only cause the tumor to grow if it's an inherited mutation b.)…

A: A mutation is a change that occurs in our DNA sequence, either due to mistakes when the DNA is…

Q: Platelet-derived growth factor (PDGF) is, as its name suggests, stored in and secreted by platelets.…

A: PDGF is naturally synthesized and stored by the body. Its primary role is to encourage the growth…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Induced pluripotent stem cells (iPS) is a type of stem cell(pluripotent) in nature that is derived…

Q: Which of the following statements about tumor suppressor genes is FALSE? a) Inactivation of tumor…

A: False statement about tumor suppressor genes.

Q: one question with multiple parts! 1A) If you were a cancer biologist interested in developing new…

A: Introduction Metastasis Is The Spread Of A Pathogenic Agent From An Initial Or Main Site Inside The…

Q: Why is it important to model cancer through the generation of induced pluripotent stem cells ?…

A: Medical technology has advanced significantly over the course of many centuries. According to…

Q: What are the normal functions of the BRCA1 tumor suppressor gene?

A: The BRCA1 gene codes for the protein that causes breast cancer type 1. BRCA1 is a human tumour…

Q: why EGFR play a role in CRC and other cancer?

A: EGFR : It is epidermis growth factor receptor.  CRC:  Colorectal cancer. EGFR : It is one of the…

Q: Heterotypic interactions of tumor cells have been a fertile area for potential therapeutic…

A: Cancer is a major disorder and it causes development of abnormal cells & they divide…

Q: 10. When a primary signal needs to be sent to most cells throughout a multicellular organism, the…

A: The answers to the above questions are given below with explanation.

Q: How interfered regulatory machinery results in production of tumor?

A: Eukaryotes have well-organized nucleus. prokaryotes are devoid of nuclear arrangements. genome…

Q: what would be the likely effect of a mutation that prevented the formation of memory cells?

A: Mutation is the sudden heritable changes that occur in the DNA sequences due to error while copying…

Q: The drug vincristine, which prevents polymerization of tubulin, is used as a chemotherapeutic agent…

A: Mechanism of actions of drug vincristine in cancer treatment.

Q: Explain why IC3 is able to stop cancerous cells from dividing ?

A: Tumor-suppressor proteins are those proteins that normally act to stop abnormal cell growth. But…

Q: Describe the roles of proto-oncogenes and tumor suppressor genes in controlling cell growth, and…

A: Oncogenesis is the process of inducing cancer in the body due to mutation in the genes. Oncogenes…

Q: Please explain the role of gene expression in the process of a stem cell differentiating into a…

A: Gene expression is the process of central dogma where protein is formed from DNA. Stem cells have…

Q: Cultured cells were treated with a compound in early Gap 1 (G₁) phase resulting to arrest before…

A: The objective of the question is to identify the most plausible mechanism of cell cycle arrest in…

Q: cAMP binds to cAMP Receptor Protein (CRP), allowing CRP to bind to the promoter of the lac operon

A: Almost all bacteria such as E. coli contains lac operon which operates in utilization of lactose as…

Q: Cancer is caused by many different types of gene mutations. Some mutations are in proto-oncogenes,…

A: Cells split into new cells so that the body uses them and cancer starts with this wonderful…

Q: illustrate some of the molecular mechanisms leading from loss-of-function mutations in…

A: Tumor suppressing genes also known as Anti - oncogenes are the  regulatory genes which regulates…

Q: Most human viruses associated with cancers activate:  a.) nuclear factor-kB (NF-kb) b.) apoptosis…

A: Cancer is a pathological condition characterized by uncontrolled cell division, proliferation and…

Q: cientists used a Rat6-Raf transformed cell line for the anchorage-independent growth control…

A: The Rat6-Raf cell line is a transformed cell line that contains an activated form of Raf. In this…

Q: Rb and Ink4 Cdk inhibitors are able to slow cell cycle progression. : a) True b) False

A: The cell cycle is a series of events that occur in a cell leading to its division and duplication.…

Q: Briefly outline the location, isolation , characterisation, benefits, and limitations of adult stem…

A: The definition of a stem cell is a unspecialized cell that can renew itself and, in some cases,…

Q: xplain the data below and why knockout of Angpt2, MMP3 and MMP10 appears to inhibit metstastasis.

A: MMP stands for matrix metalloproteinase is a multi-functional factor that plays a crucial role in…

Q: The "initiation" stage of cancer refers to:     a)  The stage where DNA is mutated, and permanent…

A: Introduction :  Cancer is defined by the following characteristics: • Uncontrolled…

Q: Can you please answer 19, and 20 please

A:

Q: The palladin gene, which plays a role in pancreatic cancer (see theintroduction to this chapter), is…

A: A disease is an abnormal condition that negatively impacts the structure and function of an…

Q: What would be the effect of a mutation that inactivates the p14ARF tumor suppressor upon p53…

A: p53 is known as a cellular tumor antigen 53 is a protein found in vertebrates that is responsible…

Q: Define the following terms: a. cell transformation b. oncogene c. apoptosis d. early response gene…

A: Gene regulation is the mechanism that acts to induce or repress the expression of the gene.that…

Q: Which of the following statements about cancer is false? (a) oncogenes arise from mutations in…

A: Proto Oncogenes are the genes that cause cancer when there are alterations in them. Several factors…

Q: 1. (a)  Binding of inducer protein to repressor protein     Gene is switched ON     Gene is…

A: Gene regulation is done with the help of the regulatory protein binding with the regulatory sequence…

Q: Repressors bind toa) Promoterb) Enhancerc) Operatord) Hormone response element

A: A repressor is a protein that can bind to DNA or RNA and inhibits gene expression. The DNA-binding…

Q: How does the epithelial-to-mesenchymal transition (EMT) contribute to tumorigenesis and disease…

A: Epithelial-mesenchymal transition (EMT) could be a method within which epithelial cells acquire…

Q: is a normal cellular gene that through a A an oncogene. OA) proto-oncogene...loss-of-function OB)…

A: An oncogene is a cancer-causing gene that has been mutated. A proto-oncogene is a type of oncogene…

Q: Which of the following statements are correct about the ability of cancer cells to form a secondary…

A: Metastasis is the property of tumor cells to develop a secondary tumor at a site away from that of…

Q: 1). Tumor suppressor proteins monitor DNA and detect damage. Some cancers evade this detection by…

A: Tumor suppressor proteins helps to control cell growth and activated in response to DNA damage and…

Cell Signaling

It allows cells to perform various cellular activities, coordinate, and interact with other cells. All cells of an organism receive signals from their environments and respond accordingly. Even the unicellular eukaryotes receive signals secreted by other cells and respond. In the case of yeast, mating takes place by signaling between the yeast cells. Communication by cell signaling in a multicellular organism has become a vast and important part of various fields of biology.