Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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Compare and contrast nonsense mutations, silent mutations, and missense mutations including the impact of the mutation on the protein produced. Your answer should be 3-7 sentences sentences long and fully explain how they are similar and what is different between the mutations.
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- Options for answers in the above picture - pick one. A. H-NS B. IHF C. Histone H1 D. DPS E. Fisarrow_forwardPlease help me, this is from practice, double check your answers, previous tutors got it wrongarrow_forwardG-LO37 Identify the consequences of mutations in different regions of a gene. The image below represents two strands of DNA: the top one corresponds to a healthy individual, and the bottom one of a sibling potentially affected with a disease due to genetic mutations Mutation 1 A + с AUA ACA AUG Met ACG GUU GUC GUA GUG Val GCU GCC GCA GCG It will result in mRNA produced Mutation 2 It will result in no mRNA produced 500 AGG The protein produced will be normal 500 + GGG Ala The Select all that applies about Mutation 1 (position -6): AAGLys AGA Arg GGU GGC GGA GGG GAC Asp GAA Glu GAGJ Gly The protein produced will have a different amino acid 1235 ATT 1235 TTT 070 2070 ALL The mutation occurs in the promoter region, and this means that the mRNA cannot be produced 1535 The mRNA and protein will both be normal because the mutation occurs outside of the consensus region of the promoter G 1535 с Affectedarrow_forward
- What is the mRNA, amino acid, and type of mutationarrow_forwardRandom mutation in the DNA sequence of a coding gene can lead to different genetic outcomes. Provide two examples of how a mutation can lead to changes in a gene’s function and how this mutation could modify the gene.arrow_forwardWhich of the following mutations in the protein-coding region of a gene is more likely to lead to complete loss of function of the encoded protein: an insertion of six nucleotides or a deletion of two nucleotides? Briefly explain your answer.arrow_forward
- Discuss the following mutations with reference to specific genetic disorders: i) Faulty DNA repair; ii) Gain-of-function; and iii) Trinucleotide repeats. Give steps for each mutations.arrow_forwardHaemochromatosis is a recessive disorder caused by mutations in the HFE gene. The disorder can be the result of nonfunctional HFE protein, or from very low levels (expression) of the HFE protein. Below is a northern blot gel showing the amount and size of HFE mRNA for a person who does not have haemochromatosis (WT). The mRNA was loaded at the top of the gel. WT A B C D Position the bands on the gel shown in each question as directed. Part 1 Tom has a mutation which changes the sequence of an enhancer region adjacent to the TATAA box for this gene. Position Tom's band in Lane A. WT A B 00arrow_forward
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