Column A Column B a. four extracellular domains 1. regions exhibiting the highest amount of diversity between T-cell receptors b. T-cell receptor complex 2. resembles a Fab fragment of IgG c. complementarity- determining regions (CDRS) 3. T-cell receptor, CD3 complex plus chains d. Vą and Vp domains 4. found on small subset of T-cell population e. y:8 T-cell receptor 5. membrane-distal loops forming antigen-binding site

Column A Column B a. four extracellular domains 1. regions exhibiting the highest amount of diversity between T-cell receptors b. T-cell receptor complex 2. resembles a Fab fragment of IgG c. complementarity- determining regions (CDRS) 3. T-cell receptor, CD3 complex plus chains d. Vą and Vp domains 4. found on small subset of T-cell population e. y:8 T-cell receptor 5. membrane-distal loops forming antigen-binding site

BIOLOGY:CONCEPTS+APPL.(LOOSELEAF)

10th Edition

ISBN:9781305967359

Author:STARR

Publisher:STARR

Chapter34: Immunity

Section: Chapter Questions

Problem 6SA

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This immune cell is able to respond quickly after any subsequent encounter with the samo antigen Oa antigen presenting cell O b. memory cell neutrophil Od. planma cell QUESTION 19 The following events occur during a T-dependent humoral imeune response. Put them in the conect order U CD, cell along with T coll receptor recognizes he antigen on the APC and forms a complex 2 Planima celin are fomed and startsecreting antbodies 3H coll digents the antigen and displays it complexed with MHC I marke AJ CD. cell diflerentiates into a Thelper cell (Th2) 5E cell phagocytoses an antigen, 6) Th2 secretes cytokines to activate the B celi and undergo cional expansion O1,3, 5, 4. 6. 2 O b.1, 5, 4. 2, 6 3 Oc. 5, 3 4, 1, 2, 6 O d. 5, 3, 1, 4, 6, 2
Activation of which of the following do not cause phagocytosis to occur O Pattern Recognition Receptors O Fc Receptors O B-Cell Receptor T-Cell Receptor
1. Which of the following statements about CD4+ Th17 cells are true? i. Cannot form T effector memory (TEM) T cell populations ii. Require the master transcription factor RORgammaT for their development iii. Produce effector cytokines IL-17 and IL-22 which help recruit neutrophils and stimulate antimicrobial peptide production iv. Do not require the transcription factor NFAT for IL-2 production downstream of TCR activation v. Important for defense against intracellular bacterial infection only a. i and iii b. ii and v c. ii and iii d. ii, iii, iv e. i, ii, and iv
eds Antibodies (Immunoglobulins) Objective 14 Antibodies (immunoglobulins) are glycoproteins secreted by plasma cells. They are located in interstitial fluid, plasma (gamma globulin fraction) and in body secretions. onse A. Antibody Structure Heavy chain Antigen-binding site Light chain Insmakamos Hinge region Complement- binding site Stem region Macrophage binding site OHO (a) Antibody molecule OHO X = Disulfide bond Carbohydrate four polypeptide chains (two heavy, two light) chains are held together by covalent disulfide bonds (S=S) each heavy chain and each light chain has two functional areas: consists of highly variable amino acid sequences which forms the basis of antibody specificity; antigen binds here ????? to more conserved amino acid sequences; there are five basic sequences of amino acids, which define the 5 antibody classes (IgG, IgA, IgM, IgE and IgD); ????? each class has its own characteristic set of effector functions (see next page) Your notes: 4 40 4. 39
T cell I ' A comparison of B and T cell maturation. List the locations and what is happening genetically, and on the surface HSC Pro Immature Mature B cells Location Genetics Receptor type Functional (y/n) Location Genetics Receptor type Functional Pre Large Small Double ++ Single ++ 3
Which are with Helper T-cells? Select all that apply. 7 CD4 0 CD8 O Release perforin O Exogenous antigen processing M Secrete IL-2 O Endogenous antigen processing O Secikte granzymes O Recognize MHC-Il molecules - Eliminate intracellular pathogens O The primary cell type that the HI-virus infects O Antigen must be presented to a Helper T-cell by an APC
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Match the term with its correct description. Transcription factor required for T-cell development Composed of superdimer, CD3 and zeta chain Facilitates the expression of tissue-specific genes in thymic epithelium Selection for thymocytes which recognize self MHC molecules Elimination of thymocytes which recognize self ✓Choose... Negative selection Notch 1 Pre-T-cell receptor Positive selection AIRE Choose... ➡
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