Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN: 9780134580999
Author: Elaine N. Marieb, Katja N. Hoehn
Publisher: PEARSON
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- If a centrocyte does not interact with antigen and engage CD40 shortly after its derivation, then Select one: a. it recommences somatic hypermutation b. it undergoes apoptosis C. it moves back into the dark zone of the germinal center and switches its isotype d. its surface immunogloblulin levels decrease and proliferation recommences.arrow_forwardHelper T cells can be activated by macrophages(which engulf everything indiscriminately) or by B cells (which only engulf antigens that stick to their receptors). A. What properties so macrophages and B cells have ibn common that allows them both to activate T cells? B. It has been suggested that macrophages probably do most to fhte T cell activating in the primary response but B cells do most of it in the secondary response. Why does this make sense?arrow_forwardYou are studying SARS-COV2. You identify a viral protein that results in the decrease of MHC class I, a cell surface receptor, on the cell surface. You are trying to determine the mechanism for how the virus is decreasing cell surface MHC I. You decide to do an experiment to determine whether the receptor is making it all of the way through the secretory pathway. You take two samples of cells. 1. Uninfected 2. Infected with SARS-CoV2 You treat them with EndoH and analyze MHC I on a western blot and get the following results: 1. Uninfected cells - 50% of protein is endo H sensitive and 50% is Endo H resistant 2. SARS-COV2 infected cells - 100% of protein is Endo H sensitive How would you best interpret these results? Is MHC I going all the way through the secretory pathway in infected cells? A. No, MHC I is not going all the way through the secretory pathway. 100% of the protein is EndoH sensitive in infected cells, this means that the virus is somehow inhibiting the protein from making…arrow_forward
- Explain why each choice (a-d) is correct or incorrect. In order for an antigen to activate or sensitize a T helper cell, the antigen must be a. coated with antibodies b. displayed on the surface of an APC along with MHC antigens c. displayed on the surface of another T cell with IgD antibodies d. partly digested by a natural killer cellarrow_forwardHow is clonal selection related to the vast number of possible B and T-cell receptor binding conformations? Draw a picture to illustrate your explanation.arrow_forward
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