A protein called trypsin, which plays a role in digestion, is made bypancreatic cells and secreted from those cells. Starting with a sampleof pancreatic cells, a researcher modified the gene that encodes trypsin by mutating the ER signal sequence so it was no longer recognized by SRP. How would this mutation affect the targeting of trypsin?

How would a human cell normally change its expression of the gene for tyrosine aminotransferase? adipose cells will turn on this gene in the presence of glucocorticoids liver cells will turn on this gene in the presence of glucocorticoids liver cells will turn on this gene in the absence of glucocorticoids liver cells will turn off this gene in the presence of glucocorticoids  adipose cells will turn off this gene in the absence of glucocorticoids

You plan to synthesize a peptide to be used as a vaccine to treat melanoma, a particularly aggressive form of skin cancer. Normally, gp100, a protein on the surface of melanocytes, activates cell growth when it is bound by its ligand. Activation of the growth pathway depends on the presence of threonine in the ligand. The effective peptide vaccine will mimic the natural ligand, but won’t cause cell growth and division. Below is the sequence of the natural ligand:   LDMKTAG   In order to ensure your newly designed peptide vaccine does not cause cell growth upon binding, you must substitute the Threonine residue at position 5. What amino acid would you replace it with, bearing in mind that the peptide should still be similar enough to bind to the gp100 protein in the surface of melanocytes. Explain your choice. Your vaccine will be administered as a topical cream, and you require your peptide to have an overall neutral charge in order to be functional. At what pH should you formulate…

Mutations to SRP72 (the RNA component of the signal recognition particle) are known to cause some forms of familial bone marrow failure. Which of the following protein(s) is/are potentially affected by such deleterious mutations? Choose all that apply Epidermal growth factor receptor (EGFR) Cytochrome c Insulin (a secreted protein) uS7 (a small ribosamal subunit protein from all dornains of life) DO00