TCR and CD28 signaling together leads to maximal production of IL-2 by the activated T cell. Experiments investigating the mechanism underlying the CD28 co-stimulation-mediated increase in IL-2 production show that T cells stimulated through the TCR plus CD28 have increased levels of IL-2 mRNA compared to cells stimulated through the TCR alone. One important component contributing to increased IL-2 mRNA levels is increased mRNA stability after transcription and splicing. increased glucose metabolism due to increased production of glycolytic enzymes. increased protein synthesis due to increased production of ribosomes. enhanced mRNA transport from the nucleus to the cytoplasm.
TCR and CD28 signaling together leads to maximal production of IL-2 by the activated T cell. Experiments investigating the mechanism underlying the CD28 co-stimulation-mediated increase in IL-2 production show that T cells stimulated through the TCR plus CD28 have increased levels of IL-2 mRNA compared to cells stimulated through the TCR alone. One important component contributing to increased IL-2 mRNA levels is increased mRNA stability after transcription and splicing. increased glucose metabolism due to increased production of glycolytic enzymes. increased protein synthesis due to increased production of ribosomes. enhanced mRNA transport from the nucleus to the cytoplasm.
Human Anatomy & Physiology (11th Edition)
11th Edition
ISBN:9780134580999
Author:Elaine N. Marieb, Katja N. Hoehn
Publisher:Elaine N. Marieb, Katja N. Hoehn
Chapter1: The Human Body: An Orientation
Section: Chapter Questions
Problem 1RQ: The correct sequence of levels forming the structural hierarchy is A. (a) organ, organ system,...
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Transcribed Image Text:TCR and CD28 signaling together leads to maximal production of IL-2 by the activated T cell. Experiments investigating the
mechanism underlying the CD28 co-stimulation-mediated increase in IL-2 production show that T cells stimulated through the
TCR plus CD28 have increased levels of IL-2 mRNA compared to cells stimulated through the TCR alone. One important
component contributing to increased IL-2 mRNA levels is
increased mRNA stability after transcription and splicing.
increased glucose metabolism due to increased production of glycolytic enzymes.
increased protein synthesis due to increased production of ribosomes.
enhanced mRNA transport from the nucleus to the cytoplasm.
0 0 0 0
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