The following electrophoresis gel has six CODIS STR markers from a crime scene DNA which is isolated from the victim's fingernails. Genetic analysis confirms that the DNA isolated from these cells came from the same individual and does not match the DNA of the victim. Analyze the electrophoresis pattern to answer the following questions. Explain whether the STR results rule out any of the three suspect. Explain whether there is a failure to exclude any of the suspects. Introduction: CODIS markers are a collection of 13 autosomal STR markers. CODIS signifies the combined DNA index system. CODIS having three levels of information, i) Local DNA Index Systems (LDIS)- here DNA profile is created. ii) State DNA Index Systems (SDIS)- it allows to sharing of data for the laboratories which are in the same states. iii) the National DNA Index System (NDIS)- it allows states to relate DNA information with one another. The CODIS markers can be utilized for linking crimes to crimes and potential suspects. The STR marker, with a number of repeats are highly variable among individuals, therefore, it is used for identification purposes. In criminal cases, DNA of a suspect is compared to a sample from the crime scene.

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Chapter E, Problem 6P

Summary Introduction

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The following electrophoresis gel has six CODIS STR markers from a crime scene DNA which is isolated from the victim's fingernails. Genetic analysis confirms that the DNA isolated from these cells came from the same individual and does not match the DNA of the victim. Analyze the electrophoresis pattern to answer the following questions.

Explain whether the STR results rule out any of the three suspect.

Explain whether there is a failure to exclude any of the suspects.

Introduction:

CODIS markers are a collection of 13 autosomal STR markers. CODIS signifies the combined DNA index system. CODIS having three levels of information, i) Local DNA Index Systems (LDIS)- here DNA profile is created. ii) State DNA Index Systems (SDIS)- it allows to sharing of data for the laboratories which are in the same states. iii) the National DNA Index System (NDIS)- it allows states to relate DNA information with one another.

The CODIS markers can be utilized for linking crimes to crimes and potential suspects. The STR marker, with a number of repeats are highly variable among individuals, therefore, it is used for identification purposes. In criminal cases, DNA of a suspect is compared to a sample from the crime scene.

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