Chapter 9, Problem 18IMT

Summary Introduction

To explain:

The statement that how the sickle-cell mutations are involved in changing the shape and the structure of the protein.

Introduction:

The hemoglobin molecule is made up of four globular protein subunits namely two alpha chains and two beta chains. The amino acids in the polypeptide of the protein are joined together through peptide bonds in the molecules like hemoglobin. The hydrogen bonds are formed between these amino-acids leading to the folding and attainment of the three dimensional conformation of the protein-hemoglobin. The subunits arrange in a specific conformation to form the quaternary structure of the protein.