The statement that how the sickle-cell mutations are involved in changing the shape and the structure of the protein. Introduction: The hemoglobin molecule is made up of four globular protein subunits namely two alpha chains and two beta chains. The amino acids in the polypeptide of the protein are joined together through peptide bonds in the molecules like hemoglobin. The hydrogen bonds are formed between these amino-acids leading to the folding and attainment of the three dimensional conformation of the protein-hemoglobin. The subunits arrange in a specific conformation to form the quaternary structure of the protein.

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Chapter 9, Problem 18IMT

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The statement that how the sickle-cell mutations are involved in changing the shape and the structure of the protein.

Introduction:

The hemoglobin molecule is made up of four globular protein subunits namely two alpha chains and two beta chains. The amino acids in the polypeptide of the protein are joined together through peptide bonds in the molecules like hemoglobin. The hydrogen bonds are formed between these amino-acids leading to the folding and attainment of the three dimensional conformation of the protein-hemoglobin. The subunits arrange in a specific conformation to form the quaternary structure of the protein.

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The genetic disorder sickle-cell anemia occurs when the amino acid valine takes the place of glutamate during translation of a hemoglobin chain. Using the table of codons below, determine the mutation in DNA that produces this disorder. 1st position ✓ U C A G Select one: U C serine phenylalanine phenylalanine serine leucine serine leucine serine leucine leucine leucine leucine isoleucine isoleucine isoleucine methionine Table of mRNA Codons 2nd position valine valine valine valine proline proline proline proline alanine alaninc alanine alanine A tyrosine tyrosine a. CUC changes to C AG b. GAA changes to GUU c. CTT changes to CAT d. C A G changes to CTC stop stop threonine asparagine threonine asparagine threonine threonine histidine histidine arginine arginine glutamine arginine glutamine arginine lysine lysine G cysteine cysteine stop tryptophan aspartate aspartate glutamate glutamate serine serine arginine arginine glycine glycine glycine glycine 3rd position DCMO U С A G U C A G…

One explanation for the prevalence of the sickle cell anemia trait in the human population in Africa is homozygous individuals carrying the Val-6 mutation die from sickle cell anemia before they can be infected with malaria so it reduced the malarial incidence in Africa. mosquitoes prefer to drink blood from humans with the sickle cell anemia trait so the more people with the mutation, the more mosquitoes there are in the area. having sickle cell anemia makes one more susceptible to malaria so the two go hand in hand with one feeding the other. heterozygous individuals carrying the Val-6 mutation are less susceptible to malaria because their red blood cells are resistant to infection by the malarial parasite.

Sickle-Cell Anemia is one disease that arises from a known point mutation in a protein. This statement is: True False