Concepts of Genetics (12th Edition)
12th Edition
ISBN: 9780134604718
Author: William S. Klug, Michael R. Cummings, Charlotte A. Spencer, Michael A. Palladino, Darrell Killian
Publisher: PEARSON
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Chapter 8, Problem 24ESP
A woman who sought genetic counseling is found to be heterozygous for a chromosomal rearrangement between the second and third chromosomes. Her chromosomes, compared to those in a normal karyotype, are diagrammed to the right.
- (a) What kind of chromosomal aberration is shown?
- (b) Using a drawing, demonstrate how these chromosomes would pair during meiosis. Be sure to label the different segments of the chromosomes.
- (c) This woman is phenotypically normal. Does this surprise you? Why or why not? Under what circumstances might you expect a
phenotypic effect of such a rearrangement?
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A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?
(b) Using a drawing, demonstrate how these chromosomeswould pair during meiosis. Be sure to label the differentsegments of the chromosomes.(c) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement?
The woman in above problem has had two miscarriages. Shehas come to you, an established genetic counselor, with thesequestions:(a) If not, what is the chance that she could have a normalchild? Provide an informed response to her concerns
A man who is a carrier of a translocated 15/21 chromosome marries a genotypically normal woman.
(1). Show the possible gametes that will be formed by this man if the translocated 15/21 chromosome synapses with chromosome 21 at Prophase I.
(2). What is the probability that the first child of the couple will be a phenotypically normal girl?
(3). What is the probability that the first child of the couple will be a genetically normal boy?
A woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?
(b) Using a drawing, demonstrate how these chromosomeswould pair during meiosis. Be sure to label the differentsegments of the chromosomes.(c) This woman is phenotypically normal. Does thissurprise you? Why or why not? Under what circumstancesmight you expect a phenotypic effect of such arearrangement?
The woman in above problem has had two miscarriages. Shehas come to you, an established genetic counselor, with thesequestions:(a) Is there a genetic explanation of her frequent miscarriages?
Chapter 8 Solutions
Concepts of Genetics (12th Edition)
Ch. 8 - A human female with Turner syndrome (47, X) also...Ch. 8 - When two plants belonging to the same genus but...Ch. 8 - What is the effect of a rare double crossover (a)...Ch. 8 - Controlling the overgrowth of invasive aquatic...Ch. 8 - Controlling the overgrowth of invasive aquatic...Ch. 8 - Controlling the overgrowth of invasive aquatic...Ch. 8 - HOW DO WE KNOW? In this chapter, we have focused...Ch. 8 - Review the Chapter Concepts list on page 171....Ch. 8 - Define these pairs of terms, and distinguish...Ch. 8 - For a species with a diploid number of 18,...
Ch. 8 - What evidence suggests that Down syndrome is more...Ch. 8 - What evidence indicates that humans with aneuploid...Ch. 8 - Contrast the fertility of an allotetraploid with...Ch. 8 - Describe the origin of cultivated American cotton.Ch. 8 - Predict how the synaptic configurations of...Ch. 8 - Inversions are said to suppress crossing over. Is...Ch. 8 - Contrast the genetic composition of gametes...Ch. 8 - Human adult hemoglobin is a tetramer containing...Ch. 8 - Discuss Ohnos hypothesis on the role of gene...Ch. 8 - What roles have inversions and translocations...Ch. 8 - The primrose, Primula kewensis, has 36 chromosomes...Ch. 8 - Certain varieties of chrysanthemums contain 18,...Ch. 8 - Drosophila may be monosomic for chromosome 4, yet...Ch. 8 - Mendelian ratios are modified in crosses involving...Ch. 8 - Having correctly established the F2 ratio in...Ch. 8 - The mutations called bobbed in Drosophila result...Ch. 8 - The outcome of a single crossover between...Ch. 8 - A couple planning their family are aware that...Ch. 8 - In a cross in Drosophila, a female heterozygous...Ch. 8 - A woman who sought genetic counseling is found to...Ch. 8 - Prob. 25ESPCh. 8 - In a recent cytogenetic study on 1021 cases of...Ch. 8 - A boy with Klinefelter syndrome (47,XXY) is born...Ch. 8 - Prob. 28ESPCh. 8 - A 3-year-old child exhibited some early indication...Ch. 8 - A normal female is discovered with 45 chromosomes,...
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Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- Assume that a meiotic-nondisjunction event causes trisomy 8 in a newborn. If two of the three copies of chromosome 8 are absolutely identical, at what point during meiosis did the nondisjunction event take place?arrow_forwardA woman who sought genetic counseling is found to be heterozygousfor a chromosomal rearrangement between the second andthird chromosomes. Her chromosomes, compared to those in anormal karyotype, are diagrammed on the next page:(a) What kind of chromosomal aberration is shown?arrow_forwarda. What type of cell division mitosis, meiosis I or meiosis II is shown in this figure? b. What is the diploid number of this organism? c. Provide labels for (i) and (ii)arrow_forward
- The letters below represent genes found on different chromosome pairs. Letters that are similar represent one gene found in a pair of homologous chromosomes. Another letter represents another gene found in another pair of chromosomes. Draw how these different pairs of chromosomes behave during meiosis. Show the complete phases of meiosis for each of the following: (a) Cc (b)BbCC (c)DdEe (d) AAbbCc (e) AaBbCcDdarrow_forward(d) With the random segregation of dyads, how many possible combinations are there at the end of meiosis for a diploid number of 10? (e) If half the chromosomes of a human primary oocyte segregate into the first polar body, which degenerates, why aren't some of the different kinds of chromosomes of the diploid chromosome complement absent from the egg? (f)What is the significance of the formation of polar bodies?arrow_forwardTwo phenotypically normal parents produce an abnormal son in which chromosome 14 is missing part of its short arm but has a piece of chromosome 21 attached to it. The child also has one normal copy of chromosome 14 and two normal copies of chromosome 21. (i) With regard to chromosome 14 and 21, what do you think are the chromosomal compositions of the parent? (ii) Draw the pairing of the translocated chromosomes in the parent during meiosis and name the segregation pattern that contributes to the abnormal karyotype. (iii) State the syndrome and write the notation for this child's karyotype.arrow_forward
- The autosomal (not X-linked) gene for brachydactyly, short fingers, is dominant to normal finger length. Assume that a female with brachydactyly in the heterozygous condition is married to a man with normal fingers. What is the probability that(a) their first child will have brachydactyly?(b) their first two children will have brachydactyly?(c) their first child will be a brachydactylous girl?arrow_forwardHow many chromosomes are there in the two products of Meiosis I: N, or 2N? (Remember to count centromeres, not chromosome strands.)arrow_forwardB. A woman is a carrier of a Robertsonian translocation between chromosomes 18 and 21. (i) Her chromosome set with respect to chromosomes 18 and 21 would consist of which specific chromosomes. Please draw a DIAGRAM illustrating these chromosomes as they would appear in their unreplicated state, clearly labeling the chromosomes and the chromosome arms present. (ii) If this woman were to have a child with a man who possess a completely normal set of chromosomes, there are six different possible outcomes with respect to the combinations of chromosomes 18, 21, and Robertsonian translocation chromosome that could be present in their offspring. Please indicate the TYPES and NUMBERS of chromosomes of each type present in their potential offspring. You may label the chromosomes as follows: 18 (for chromosome 18), 21 (for chromosome 21) or 18/21 (for the Robertsonian translocation chromosome). Also, please indicate the specific genetic abnormality (if any) that would be present in…arrow_forward
- A diploid organism produces four gametes from one parent cell through the process of meiosis. Two gametes are found to have 7 chromosomes and two gametes are found to have 5 chromosomes. A) Is this the expected number of chromosomes that would be found in each gamete following a normal cycle of meiosis? If yes, explain why. If no, explain why not and describe how the gamete situation described above occurred. B) Determine the number of homologous chromosome pairs that the original parent cell contained, before meiosis began. Explain how you determined this value.arrow_forwardA specific human individual with a male sex has the same sex chromosome complement as a metafemale Drosophila fly. Both individuals have a diploid set of autosomes.i) What is the sex chromosome complement of these two individuals? ii) If these individuals were produced from a fertilization event involving an abnormal egg and abnormal sperm cell, provide the genetic make-up of the two gametes? Clearly indicate the male and female gametes.arrow_forwardMeiosis is defined as a ____. Select an answer and submit. For keyboard navigation, use the up/down arrow keys to select an answer. a) type of cell division that is seen in all types of cells b) type of cell division that divides a somatic cell and produces 4 gamete cells c) type of cell division that divides a somatic cell and produces 2 gamete cells d) type of cell division that divides a gamete cell into 2 somatic cellsarrow_forward
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