Life: The Science of Biology
11th Edition
ISBN: 9781319010164
Author: David E. Sadava, David M. Hillis, H. Craig Heller, Sally D. Hacker
Publisher: W. H. Freeman
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Chapter 7.2, Problem 2R
Summary Introduction
To review:
Discuss the chemical nature and importance of specificity in the binding of a receptor to its particular ligand.
Introduction:
A cell performs its function when a ligand binds to its specific receptor and thus produces the response that occurs through a signaling pathway. A ligand is a chemical molecule, which only binds to the specific receptor just like the lock and the key mechanism.
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Explain the Binding of the ligand to the receptor ?
Describe the process and results of receptor-ligand binding.
How does a receptor “know” which signaling molecules to bind?
Chapter 7 Solutions
Life: The Science of Biology
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- Estimate the binding affi nity of a ligand for its receptor from the followingdata:arrow_forwardUnder what conditions might receptor up-regulation occur? receptor down-regulation?arrow_forwardWhat are the three steps by which receptor tyrosine kinases typically convey an extracellular signal to another intracellular enzyme?arrow_forward
- Why is the receptor the important element determiningthe effect a neurotransmitter has on a target cell?arrow_forwardName three features common to the activation of cytokine receptors and receptor tyrosine kinases. Name one difference with respect to the enzyme activity of these receptors.arrow_forwardWhat are the sequences of events by which the binding of a chemical messenger to a receptor causes the cell to respond in a specific way?arrow_forward
- Explain whether the specificity of interaction will be high or low for each given situation. a. The value of KD of the ligand's interaction to the target receptor is very much lower than the value of KD of the ligand's interaction to off-targets. b. The ligand concentration [L] is higher than the KDÂ value of its interaction with the target and the KDÂ value of its interaction to off-targets.arrow_forwardWhat are the advantages of having an enzyme (like adenylyl cyclase) involved in the initial response to receptor activation by a first messenger?arrow_forwardWhich of the following statements most accurately describes what happens when an antagonist binds to a receptor? Â Â The antagonist binds non-covalently to the receptor and promotes internalisation of the receptor. Â Â Antagonist binding alters the structure of the receptor making it unable to function normally. Â Â At sufficiently high concentrations the antagonist can prevent the receptor from binding to its natural (endogenous) ligand. Â Â The antagonist-receptor complex binds to a heterotrimeric G protein forming a stable and inactive ternary complex.arrow_forward
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