BIOLOGY
BIOLOGY
12th Edition
ISBN: 9781260169614
Author: Raven
Publisher: RENT MCG
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Chapter 50, Problem 4S

Toll-like receptors have been found in a wide variety of organisms, including both protostomes and deuterostomes, and now in cnidarians. In addition, parts of the signaling system have been found in a wide variety of organisms as have parts of the complement system. What does this say about the evolution of innate immunity?

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For some time there has been evidence that the Bacille Calmette-Guérin (BCG) vaccine provides protection not only against the target disease (Mycobacterium tuberculosis), but also enhances responses to other infections (such as Staphylococcus aureus and Candida albicans). Do you think the enhanced response to other infections, as described, is due to innate responses to the vaccine or adaptive responses? Explain your answer.
In Lubeck, Germany, in 1930, a group of 251 infants was accidentally administered a tainted vaccine for tuberculosis that contained live Mycobacterium tuberculosis. This vaccine was administered orally, directly exposing the infants to the deadly bacterium. Many of these infants contracted tuberculosis, and some died. However, 44 of the infants never contracted tuberculosis. Based on your knowledge of the innate immune system, what innate defenses might have inhibited M. tuberculosis enough to prevent these infants from contracting the disease?
In vertebrates, complement activation generally involves a pathogen recognition step followed by a proteolytic cascade that produces the effector proteins that function in opsonization, membrane attack, and inflammation. Which of these is likely to be the most evolutionarily primitive aspect of the complement system? Which pathway of complement initiation is likely to be the one that most recently evolved?

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