Campbell Essential Biology (7th Edition)
7th Edition
ISBN: 9780134765037
Author: Eric J. Simon, Jean L. Dickey, Jane B. Reece
Publisher: PEARSON
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Chapter 5, Problem 14PS
HIV, the virus that causes AIDS, depends on an enzyme called reverse transcriptase to multiply. Reverse transcriptase reads a molecule of RNA and creates a molecule of DNA from it. A molecule of AZT, an anti-AIDS drug, has a shape very similar to (but a bit different than) that of the DNA base thymine. Propose a model for how AZT inhibits HIV.
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Tenofovir, an analog of adenosine monophosphate, is a nucleoside reverse transcriptase inhibitor used to treat HIV infection. Atazanavir, also used to treat HIV infection, is a protease inhibitor. Approximately 1 in 1,000 virus particles carries a mutation that confers resistance against any given anti-HIV drug. If there are 1010 virus particles circulating in a patient, roughly how many of them would be resistant to both tenofovir and atazanavir?
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104
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106
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107
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Proflavine was used to treat wounded soldiers in the Far East during the second world war. Which of the following statements is false regarding proflavine!
H₂N7
NH₂
Its target is located in the cell membrane.
Its planar shape is important to intercalation.
The primary amine groups are protonated and interact with phosphate groups of the DNA backbone.
When inserted into DNA, the tricyclic system can form van der Waals interactions with base pairs above and below it.
Emtricitabine (2',3'-dideoxy-5-fluoro-3'-thiacytidine, abbreviated as FTC) is a nucleoside analog that is used to treat HIV. It works by reversibly binding to HIV reverse
transcriptase (HIV RT) and by doing so, inhibits the virus from replicating itself. In an experiment, FTC and purified HIV RT are mixed at low concentrations and allowed to
reach equilibrium. The concentrations measured are [FTC] = 10 nM, [HIV RT] = 37.5 nM, and [HIV RT-FTC] = 2.5 µM, for the equilibrium FTC + HIV RT= HIV RT-FTC.
What is the Kd in nM?
Chapter 5 Solutions
Campbell Essential Biology (7th Edition)
Ch. 5 - Prob. 1SQCh. 5 - _____ is the capacity to perform work, while _____...Ch. 5 - The label on a candy bar says that it contains 150...Ch. 5 - Prob. 4SQCh. 5 - Prob. 5SQCh. 5 - Prob. 6SQCh. 5 - Prob. 7SQCh. 5 - Prob. 8SQCh. 5 - Prob. 9SQCh. 5 - Prob. 10SQ
Ch. 5 - Prob. 11IMTCh. 5 - For each statement, identify which major theme is...Ch. 5 - For each statement, identify which major theme is...Ch. 5 - HIV, the virus that causes AIDS, depends on an...Ch. 5 - Interpreting Data The graph illustrates two...Ch. 5 - Prob. 17BSCh. 5 - Nanotechnology devices can improve human health....Ch. 5 - Prob. 19BS
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