Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN: 9781285866932
Author: Lauralee Sherwood
Publisher: Cengage Learning
expand_more
expand_more
format_list_bulleted
Concept explainers
Question
Chapter 4, Problem 5TAHL
Summary Introduction
To discuss:
The usefulness of a Selective estrogen receptor modulators (SERM). The explanation of the pathway for the administration of this drug.
Introduction:
Selective estrogen receptor modulators are also known as SERMs. These are a group of drugs. These drugs act on the estrogen receptor. A distinctive feature which separates these materials from the pure ER agonists and antagonists. Their activity is unlike in various several tissues. Thus, yielding the opportunity to selectively inhibit or excite estrogen-like action in several tissues.
Expert Solution & Answer
Want to see the full answer?
Check out a sample textbook solutionStudents have asked these similar questions
Explain the mechanism of action of tamoxifen in the treatment of breast cancer
Estrogen receptor antagonists inhibit tumors by:
1) blocking estrogen binding to receptors
2) binding cell-surface receptors
3) stimulating intracellular receptors
4) binding HER2 receptors and keeping agonists from binding
A patient is prescribed drug for the treatment of his prostate cancer that blocks testosterone from binding to its intracellular receptor. Which of the following drugs has this mechanism of action?
Flutamide
Tamoxifen
Leuprolide
Sunitinib
Chapter 4 Solutions
Human Physiology: From Cells to Systems (MindTap Course List)
Ch. 4.1 - Name the two types of excitable tissue.Ch. 4.1 - Prob. 2CYUCh. 4.1 - State the factor responsible for triggering gate...Ch. 4.2 - Prob. 1CYUCh. 4.2 - Prob. 2CYUCh. 4.2 - Prob. 3CYUCh. 4.3 - Draw and label an action potential, indicating the...Ch. 4.3 - Prob. 2CYUCh. 4.3 - Prob. 3CYUCh. 4.3 - Prob. 4CYU
Ch. 4.4 - Explain why synapses operate only in the direction...Ch. 4.4 - Prob. 2CYUCh. 4.4 - Prob. 3CYUCh. 4.4 - Prob. 4CYUCh. 4.5 - Define target cell.Ch. 4.5 - Distinguish among the four types of extracellular...Ch. 4.5 - Outline the three general means by which binding...Ch. 4.5 - Prob. 4CYUCh. 4.6 - Distinguish between cytokines and eicosanoids.Ch. 4.6 - Discuss the roles of phospholipase A2,...Ch. 4.6 - Prob. 3CYUCh. 4.7 - Prob. 1CYUCh. 4.7 - Prob. 2CYUCh. 4.7 - Prob. 3CYUCh. 4.8 - Prob. 1CYUCh. 4.8 - Prob. 2CYUCh. 4 - Conformational changes in channel proteins brought...Ch. 4 - Prob. 2RECh. 4 - Prob. 3RECh. 4 - Prob. 4RECh. 4 - Second-messenger systems ultimately bring about...Ch. 4 - Each steroidogenic organ has all the enzymes...Ch. 4 - Prob. 7RECh. 4 - Prob. 8RECh. 4 - Prob. 9RECh. 4 - Prob. 10RECh. 4 - Prob. 11RECh. 4 - Prob. 12RECh. 4 - Prob. 13RECh. 4 - A common membrane-bound intermediary between the...Ch. 4 - Prob. 15RECh. 4 - Prob. 16RECh. 4 - Prob. 17RECh. 4 - Prob. 18RECh. 4 - Define the following terms: polarization,...Ch. 4 - Prob. 2UCCh. 4 - Prob. 3UCCh. 4 - Prob. 4UCCh. 4 - Compare the four kinds of gated channels in terms...Ch. 4 - Prob. 6UCCh. 4 - Prob. 7UCCh. 4 - Prob. 8UCCh. 4 - Prob. 9UCCh. 4 - Define signal transduction.Ch. 4 - Compare the tyrosine kinase and JAK/STAT pathways.Ch. 4 - Prob. 12UCCh. 4 - Prob. 13UCCh. 4 - Describe how arachidonic acid is converted into...Ch. 4 - Prob. 15UCCh. 4 - Prob. 16UCCh. 4 - Explain how the cascading effect of hormonal...Ch. 4 - Prob. 18UCCh. 4 - Answer the following questions regarding...Ch. 4 - Prob. 2SQECh. 4 - Prob. 3SQECh. 4 - Prob. 1ACRCh. 4 - The rate at which the Na+K+ pump operates is not...Ch. 4 - Which of the following would occur if a neuron...Ch. 4 - Prob. 3TAHLCh. 4 - Assume presynaptic excitatory neuron A terminates...Ch. 4 - Prob. 5TAHL
Knowledge Booster
Learn more about
Need a deep-dive on the concept behind this application? Look no further. Learn more about this topic, biology and related others by exploring similar questions and additional content below.Similar questions
- describe the outcome of EGFR inhibition as well as the differences between erlotinib and panitumumab’s mechanisms of action. EGFR- driven cancer cells can become resistant to tyrosine kinase inhibitors. Explain the two types of EGFR blockade acquired resistance and propose a subsequent treatment option.arrow_forwardIn a breast cancer patient whose tumor cells express large amounts of estrogen receptors and are therefore very sensitive to estradiol, which of these drugs will be very effective in reducing plasma levels of estradiol and consequently the breast tumor growth? Group of answer choices Letrozole Paclitaxel Methotrexate Megestrolarrow_forwardIs EGFR and KRAS involved in lung cancer brain metastasis? Explain.arrow_forward
- Explain the following mechanisms of action of peptide and steroid hormones in its target cells. i. Cyclic adenosine monophosphate (cAMP) mechanism. ii. Phosphatidylinositol biphosphate-calcium (PIP-Ca) mechanism. iii. Direct gene activation mechanismarrow_forwardA patient with end-stage prostate cancer is in severe pain. Which of the following medications would be prescribed to this patient? Select two drug classifications indicated for the client: Depolarizing agents Narcotic antagonist Centrally-acting muscle relaxant Amides Narcotic agonist-antagonistarrow_forwardAlthough numerous treatments are available for advanced hormone receptor- positive (HR+) and human epidermal growth factor receptor 2 negative (HER2-) breast cancers, they are rarely curable. Drugs such as palbociclib that inhibit cyclin-dependent kinase 4 and 6 (CDK4/6) are rapidly altering this therapeutic environment. Discuss the function of CDK4 and CDK6 in promoting cell growth as well as the overall effects of their inhibition by palbociclib on the progression of the cell cycle.arrow_forward
- Discuss the advantages and disadvantages of general chemotherapy like Etoposide compared to specific inhibition of EGFR.arrow_forwardA 62-year-old patient is receiving methyltestosterone (Methitest), 200 mg PO daily, for palliation of breast cancer. She asks you why she is taking this particular medication and expresses concern that this medication, like other medications she has taken for treatment of the cancer, will make her feel ill. What should you tell her?arrow_forwardRecently, a Gα q-coupled receptor was discovered that mediates at least some of the many activities of estrogen. At the time, this discovery generated considerable controversy, as it ran counter to what was then the understanding of how steroid hormone signaling worked. Which of the following observations might have led the investigators to suspect the existence of this newly discovered receptor? A. Activities of estrogen apparent less than 1 minute after application of the hormone B. The growth promoting activity of estrogen C. The presence of estrogen nuclear receptors in cells not previously known to respond to the hormone D. Estrogen is found in much higher concentrations in adult women than adult men E. Uptake of estrogen by target cellsarrow_forward
- Opioids cross the placental barrier, and a newborn of opioid-dependent mother will undergo withdrawal within 6-12 hours of birth. The long-term consequences of prenatal opioid dependence are poorly understood, but it may be best practice to maintain the mother on methadone and treat the infant with opioid rather than withdraw the mother before child delivery. Give some examples of drugs that can be used to reverse withdrawal and which medications can be used for opioid dependence treatment?arrow_forwardAducanumab is a human antibody treatment strategy currently undergoing phase III clinical trials in Alzheimer’s disease. This acts by: (choose all that apply) increasing cholinergic stimulation selectively inhibiting serotonin stimulating dopamine receptors reducing the production of Aβ plaques promoting neurogenesis reducing neurofibrillary tanglesarrow_forwardHerceptin is an antibody that is used to treat certain forms of breast cancer by binding to a class of estrogen receptors. What is the basis for its effectiveness in treating certain forms of breast cancer?arrow_forward
arrow_back_ios
SEE MORE QUESTIONS
arrow_forward_ios
Recommended textbooks for you
- Human Physiology: From Cells to Systems (MindTap ...BiologyISBN:9781285866932Author:Lauralee SherwoodPublisher:Cengage LearningEssentials of Pharmacology for Health ProfessionsNursingISBN:9781305441620Author:WOODROWPublisher:Cengage
Human Physiology: From Cells to Systems (MindTap ...
Biology
ISBN:9781285866932
Author:Lauralee Sherwood
Publisher:Cengage Learning
Essentials of Pharmacology for Health Professions
Nursing
ISBN:9781305441620
Author:WOODROW
Publisher:Cengage
What is cancer? What causes cancer and how is it treated? *UPDATE*; Author: Cancer Treatment Centers of America - CTCA;https://www.youtube.com/watch?v=_N1Sk3aiSCE;License: Standard Youtube License