Human Physiology: From Cells to Systems (MindTap Course List)
9th Edition
ISBN: 9781285866932
Author: Lauralee Sherwood
Publisher: Cengage Learning
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Chapter 4, Problem 3RE
Summary Introduction
To Determine:
If the given statement 'after an action potential, the potassium ion concentration is higher outside the cell than inside the cell because of the efflux of during the falling phase' is true or false should be determined.
Introduction:
An action potential can be defined as a quick rise and a subsequent decrease in voltage or membrane potential through a cellular membrane with a distinguishing pattern. Synapse is a junction present between the two neurons.
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Which of the following intracellular potentials would have the greatest electrical
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-70mV
Ⓒ) -100mV
-50mV
OmV
+20mV
a) Explain in detail what is occurring at stage A in the graph. (Be specific in terms of
what's happening to the ion channels in your explanation if necessary!)
b) What does this graph represent as a whole? Explain the main idea it portrays.
+40|
-70-
A
1
2
4
Time/ms
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B
The resting membrane potential is a negative value because of:
Chapter 4 Solutions
Human Physiology: From Cells to Systems (MindTap Course List)
Ch. 4.1 - Name the two types of excitable tissue.Ch. 4.1 - Prob. 2CYUCh. 4.1 - State the factor responsible for triggering gate...Ch. 4.2 - Prob. 1CYUCh. 4.2 - Prob. 2CYUCh. 4.2 - Prob. 3CYUCh. 4.3 - Draw and label an action potential, indicating the...Ch. 4.3 - Prob. 2CYUCh. 4.3 - Prob. 3CYUCh. 4.3 - Prob. 4CYU
Ch. 4.4 - Explain why synapses operate only in the direction...Ch. 4.4 - Prob. 2CYUCh. 4.4 - Prob. 3CYUCh. 4.4 - Prob. 4CYUCh. 4.5 - Define target cell.Ch. 4.5 - Distinguish among the four types of extracellular...Ch. 4.5 - Outline the three general means by which binding...Ch. 4.5 - Prob. 4CYUCh. 4.6 - Distinguish between cytokines and eicosanoids.Ch. 4.6 - Discuss the roles of phospholipase A2,...Ch. 4.6 - Prob. 3CYUCh. 4.7 - Prob. 1CYUCh. 4.7 - Prob. 2CYUCh. 4.7 - Prob. 3CYUCh. 4.8 - Prob. 1CYUCh. 4.8 - Prob. 2CYUCh. 4 - Conformational changes in channel proteins brought...Ch. 4 - Prob. 2RECh. 4 - Prob. 3RECh. 4 - Prob. 4RECh. 4 - Second-messenger systems ultimately bring about...Ch. 4 - Each steroidogenic organ has all the enzymes...Ch. 4 - Prob. 7RECh. 4 - Prob. 8RECh. 4 - Prob. 9RECh. 4 - Prob. 10RECh. 4 - Prob. 11RECh. 4 - Prob. 12RECh. 4 - Prob. 13RECh. 4 - A common membrane-bound intermediary between the...Ch. 4 - Prob. 15RECh. 4 - Prob. 16RECh. 4 - Prob. 17RECh. 4 - Prob. 18RECh. 4 - Define the following terms: polarization,...Ch. 4 - Prob. 2UCCh. 4 - Prob. 3UCCh. 4 - Prob. 4UCCh. 4 - Compare the four kinds of gated channels in terms...Ch. 4 - Prob. 6UCCh. 4 - Prob. 7UCCh. 4 - Prob. 8UCCh. 4 - Prob. 9UCCh. 4 - Define signal transduction.Ch. 4 - Compare the tyrosine kinase and JAK/STAT pathways.Ch. 4 - Prob. 12UCCh. 4 - Prob. 13UCCh. 4 - Describe how arachidonic acid is converted into...Ch. 4 - Prob. 15UCCh. 4 - Prob. 16UCCh. 4 - Explain how the cascading effect of hormonal...Ch. 4 - Prob. 18UCCh. 4 - Answer the following questions regarding...Ch. 4 - Prob. 2SQECh. 4 - Prob. 3SQECh. 4 - Prob. 1ACRCh. 4 - The rate at which the Na+K+ pump operates is not...Ch. 4 - Which of the following would occur if a neuron...Ch. 4 - Prob. 3TAHLCh. 4 - Assume presynaptic excitatory neuron A terminates...Ch. 4 - Prob. 5TAHL
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- Conformational changes in channel proteins brought about by voltage changes are responsible for opening and closing Na+ and K+ gates during the generation of an action potential. (True or false?)arrow_forwardHyperkalemia is a condition by which ECF potassium levels become too high (usually due to kidney failure). Consider the following questions about the consequence of hyperkalemia on membrane potential. How would hyperkalemia affect EK? Considering your answer to the previous question, how would hyperkalemia affect membrane potential?arrow_forwardHyperpolarization is defined as an increase in membrane potential toward zero. True Falsearrow_forward
- Describe the action potential in terms of the different functional states of the voltage- gated Na+ membrane channels (Note: there are three states)arrow_forwardVoltage-gated K+ channel senses voltage across the plasma membrane and permits selective passage of K+ ions. True Falsearrow_forwardSevere burns, particularly third-degree burns that damage a significant portion of the body surface, can result in the release of sodium from damaged cells into the bloodstream leading to hypernatremia. Note: Words with the suffix '-emia' generally indicate a presence of a substance or condition in the blood. Question: Based on this information, which of the following statement/s is/are true? ☐ Hypernatremia would lead to a greater Na* influx through voltage-gated Na* channels. This increased Na* influx would cause the cell to reach threshold faster and increase cell excitability. ☐ Hypernatremia can result in more negative resting membrane potential due to the reduced efflux of Na+ ions. Consequently, this may lead to a decrease in the rate of action potential generation in excitable cells. Hypernatremia can result in a more positive resting membrane potential due to the increased influx of K+ ions. Consequently, this may lead to a decrease in the rate of action potential generation…arrow_forward
- Describe the ion movement across the cell membrane during the following stages: resting potential, threshold potential, depolarization, repolarization.arrow_forwardWhich of the following phases of an action potential is correctly matched with the changes in ion movement and membrane potential? All of these are correctly matched. Phase 1 – sodium movement into the cell Phase 3 – potassium movement into the cell Phase 2 – sodium movement out of the cellarrow_forwardA change in membrane potential which is due to ion influx or efflux in a single region with the ions then diffusing away from that region is called a(n) ______arrow_forward
- The normal concentrations for intracellular and extracellular potassium in a neuron are [K+]in = 150 mM and [K+]out = 5 mM, respectively. Due to an electrolyte imbalance, a patient has the following intracellular and extracellular concentrations of potassium: [K+]in = 140 mM and [K+]out =2 mM. Using the Nernst equation (Chapter 4), calculate the equilibrium potential for potassium in the cells with normal K+ distributions and of the diseased patient. Refer back to Question #1. Will it be easier or more difficult to generate an action potential in the diseased neuron as compared to the normal neuron? Why?arrow_forwardMark the following statements as true or false. If a statement is false, correct it to make a true statement. a. The resting membrane potential refers to the voltage difference across the membranes of excitable cells at rest. b. The concentration of Na+ is highest in the cytosol, and the concentration of K+ is highest in the extracellular fluid. c. The Na+>K+ pumps and gated channels maintain the Na+ and K+ gradients necessary for action potentials to occur. d. A depolarization is a change in membrane potential that makes the potential less negative. e. A local potential is a change in membrane potential that conducts the long-distance signals of the nervous systemarrow_forwardAt the peak of an action potential, would the relative permeability of Na be higher than K? Which ion would be the least permeable to the membrane during falling phase?arrow_forward
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