describe the outcome of EGFR inhibition as well as the differences between erlotinib and panitumumab’s mechanisms of action. EGFR- driven cancer cells can become resistant to tyrosine kinase inhibitors. Explain the two types of EGFR blockade acquired resistance and propose a subsequent treatment option.

TNF-alpha treatment of prostate carcinoma, LNCAP cells decreases cell survival as shown in the graph below. Which of the following would you observe in these cells treated with TNF- alpha? Select all that apply TNF-a 120 100 80 - 60- 40- 20 - 24 72 (hrs) + Control - TNF-a 10ng + TNF-a 100 ng O Activation of extrinsic pathway of apoptosis O Activation of intrinsic pathway of apoptosis Activation of executioner caspases Recruitment of adapter protein FADD to the TNF-alpha receptor LNCAP cell viability (% of control)

Suppose that you measured binding to the isolated EGF receptor of EGFat various concentrations. Would you expect the binding curve to be hyperbolic? Explain your answer.

The number of calories used during physical exercise is greater than the number of calories used for the movements themselves. This may be caused in part by exercise-induced expression of uncoupling protein 1 (UCP1) in subcutaneous fat. Subcutaneous fat is mostly white fat cells but can also contain brown fat cells in mice and humans. As part of a thermogenesis program, UCP1 directly reduces the proton gradient driving oxidative phosphorylation. UCP1 expression is a characteristic of brown fat cells only and is induced by the protein irisin. The data in Table 1 address the relationship between exercise and: • expression of UCP1 in subcutaneous fat cells, • expression of FNDC5 (a transmembrane protein in skeletal muscle plasma membranes), • blood levels of irisin (a soluble protein formed by cleaving the extracellular domain of FNDC5), and • expression of adiponectin (a hormone produced by white fat cells) in both wild-type mice and mice with overexpression skeletal muscle PGC-1a (a…

Why is there caution against prescribing imatinib with strong CYP3A4 inhibitors?

Estimate the concentration of norepinephrine at which the response reaches 50% (disregard that there are two curves) express the concentration in microM. List the concentrations at which the response was tested.

Based on data, which aptamer would consider to be the primary receptor for the FGF5 ligand? Explain your answer.

Questions are either true or false about for the following statements on Notch signaling  please help. how do i work throuhg these During R8 determination, cells with higher Notch ligand Dl will induce higher expression of Notch target gene Enhancer of Split complexes [E(spl)] in the neighboring cells and inhibit their differentiation into R8 neurons.   In the absence of Notch ligands, Su(H) will bind to the corepressor proteins and repress Notch target gene expression. Therefore the effects of the Notch receptor mutation can be different from that of the Su(H) mutations   Notch signaling has multiple functions during eye development, including regulation of cell proliferation, lateral inhibition, selection of the first retinal neuron, and recruitment of cone cells. These different functions are all mediated by Notch signaling targets the Enhancer of Split complexes [E(spl)].   Mutations that specifically block endocytosis of Notch ligand Dl (in the Dl expressing cells) will…

Please provide explanation for each step

Biologic agents can block cell migration to sites of inflammation and reduce immune responses.  Natalizumab is a humanized monoclonal antibody directed at the a4-integrin protein, a subunit of VLA-4, the binding partner of VCAM-1 expressed on endothelium in the central nervous system, and of a4b-integrin, the binding partner of MadCAM-1 expressed on endothelium in the gut. While natalizumab has had great success in alleviating the symptoms of autoimmune diseases such as multiple sclerosis and Crohn’s disease, a small number of patients have acquired life threatening infections of the neurotrophic virus, JC. Why are patients on natalizumab particularly susceptible to a virus infection of the central nervous system?