In a breast cancer patient whose tumor cells express large amounts of estrogen receptors and are therefore very sensitive to estradiol, which of these drugs will be very effective in reducing plasma levels of estradiol and consequently the breast tumor growth? Group of answer choices Letrozole Paclitaxel Methotrexate Megestrol
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- describe the outcome of EGFR inhibition as well as the differences between erlotinib and panitumumab’s mechanisms of action. EGFR- driven cancer cells can become resistant to tyrosine kinase inhibitors. Explain the two types of EGFR blockade acquired resistance and propose a subsequent treatment option.A series of novel phenadoxone derivatives without mu2 receptor activity (mu2 activity is responsible for physical dependence) proposed to be developed as analgesics is shown below. Addition of which heterocyclic substituent R to phenadoxone is LIKELY to cause the MOST binding of the corresponding derivative to plasma proteins? Use the additivity of approximate estimates of logP to answer this question. phenadoxone derivatives A. Azetidine B. Thiophene C. Oxetane D. Furan E. Pyrrole ترف لي تي في R= -NHIn 2-page worth of words (around 500), discuss CYCLAMATE's regulation, allowable levels, and what group of people are at high risk for the side effects of CYCLAMATE in the body.
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- Explain the mechanism of action of tamoxifen in the treatment of breast cancerRelate these advantages to explain why radiopharmaceuticals are often used in the treatment of i) prostate cancer (brachytherapy) ii) thyroid cancer (iodine-131 treatment)Dexamethasone 1 Dexamethasone is a glucocorticoid administered as an anti-inflammatory agent and immunosuppressant. It is structurally similar to cortisol produced naturally by your adrenal glands. It treats a number of conditions including inflammation, arthritis, autoimmune conditions, skin and eye conditions, asthma, multiple sclerosis, blood or bone marrow disorders, different types of cancer (e.g. leukemia and lymphoma), and severe allergies. This medication is also administered to patients with severe COVID-19 symptoms to decrease mortality rates*. Given that it is a steroid, which family of macromolecules does dexamethasone belong to? *research from the University of Oxford, "Randomised Evaluation of COVID-19 Therapy" trial, recovery.net 2 Given the structures of dexamethasone (left) and cortisol (right) below, and that they both bind to the same receptor, would you expect the binding of dexamethasone to be to the active or allosteric site of the receptor? 3 Based on the…
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