Chapter 4, Problem 4.73P

Interpretation Introduction

Interpretation:

The reason for more stability of $\text{5-Hydroxy-1, 3-dioxane}$ with the OH group in the axial position than in the equatorial position is to be explained.

Concept introduction:

In monosubstituted compounds, the equatorial substituted conformer is more stable than the axial conformer due to 1, 3 diaxial interactions. But this depends on the substituent present on it. If the substituent is a hydroxyl group (OH group) present in axial position and can form hydrogen bonding with adjacent or near atoms like oxygen, then it prefers to occupy the axial position only.